Drug Class: 3rd Generation Cephalosporins

Ceftazidime

Mechanism of Action Ceftazidime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftazidime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. Mechanism of Resistance Resistance to ceftazidime is primarily through hydrolysis by beta-lactamase, alteration of penicillin-binding proteins (PBPs), and decreased permeability. …

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Cefdinir

Mechanism of Action As with other cephalosporins, bactericidal activity of cefdinir results from inhibition of cell wall synthesis. Cefdinir is stable in the presence of some, but not all, β-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins are susceptible to cefdinir. Mechanism of Resistance Resistance to cefdinir is primarily through …

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Cefpodoxime Proxetil

MOA Cefpodoxime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefpodoxime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. Brands of Cefpodoxime Proxetil available Auropodox®, Aurobindo Cacef ,galaxy Pharmaceutical Limited Cefpodox®, Unicorn Cefpowel DT , Unosource Pharma Limited Cefoprox, Cipla Ltd …

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Cefoperazone + Sulbactam

Mechanism of Action Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase-producing organisms. Brands of Cefoperazone in Kenya Bactacef, Swiss Parenterals (Pvt.) Ltd Cebanex, Orchid Cefobact ,Inject Care Parenterals Pvt. Ltd Cefocel, Zawadi Healthcare Ltd Cesalac, …

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Ceftriaxone

Mechanism of Action Ceftriaxone is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftriaxone has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. Mechanism of Resistance Resistance to ceftriaxone is primarily through hydrolysis by beta-lactamase, alteration of penicillin-binding proteins (PBPs), and decreased permeability. …

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Ceftriaxone / Sulbactum

Mechanism of Action Ceftriaxone is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftriaxone has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the …

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