Cefoperazone + Sulbactam

Mechanism of Action
Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase-producing organisms.

Brands of Cefoperazone in Kenya

Bactacef, Swiss Parenterals (Pvt.) Ltd
Cebanex, Orchid
Cefobact ,Inject Care Parenterals Pvt. Ltd
Cefocel, Zawadi Healthcare Ltd
Cesalac, Flamingo
Fytobact ,cadila Pharmaceuticals (EA) Ltd
Injlin , Inject Care Parenterals Pvt Ltd
Inno-bact , Innocia Lifesciences Pvt. Ltd.
Cefoperazone is a third-generation cephalosporin antibiotic
It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics.
Cefoperazone/sulbactam is a co-formulation with sulbactam.
It was patented in 1974 and approved for medical use in 1981

Spectrum of bacterial susceptibility

Cefoperazone has a broad spectrum of activity and has been used to target bacteria responsible for causing infections of the respiratory and urinary tract, skin, and the female genital tract. The following represents MIC susceptibility data for a few medically significant microorganisms.

  • Haemophilus influenzae: 0.12 – 0.25 µg/ml
  • Staphylococcus aureus: 0.125 – 32 µg/ml
  • Streptococcus pneumoniae: ≤0.007 – 1 µg/ml


Cefoperazone contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase
A disulfiram-like event ,may occur when used with alcohol.,this has been attributed to the N-methylthiotetrazole (NMTT or 1-MTT) side chain . Patients should avoid alcohol during treatment
Probenecid : may decrease renal clearance of Cefoperazone

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