Brands of Tenonitrozole in Kenya:
Atrican®, Innotech
Tenonitrozole Mode of Action:
Tenonitrozole is a Selective for anaerobic bacteria due to their ability to intracellularly reduce imidazole which covalently binds to DNA, disrupts its helical structure, inhibiting bacterial nucleic acid synthesis.
TENONITROZOLE INDICATIONS:
Tenonitrozole is a Nitroimidazole given in the treatment of trichomoniasis. It is given orally in a dose of 250 mg twice daily with meals, for 4 days.
CONTRAINDICATIONS:
Tenonitrozole is contraindicated in pregnancy and breastfeeding
Tenonitrozole is contraindicated in hepatic insufficiency.
This medication is generally not recommended in combination with alcohol.
PRECAUTIONS:
Alcohol should be avoided while taking Tenonitrozole, because of Disulfiram-like effects
ADVERSE EFFECTS:
mild digestive disorders: nausea, feelings of gastric heaviness, loss of appetite.
Yellow coloring of contact lenses.
Reporting of suspected adverse reactions
The PPB Department of Pharmacovigilance was set up with a vision to develop, implement and continuously upgrade an appropriate system for detecting, reporting and monitoring adverse drug reactions (ADRs) and other relevant problems with medicines in Kenya. The department strives to ensure the safety and efficacy of pharmaceutical products in Kenya.
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals/ Patients are encouraged to report any suspected adverse reactions via Pharmacovigilance Yellow Form, pv@pharmacyboardkenya.org or clicking below button:
Clinical | Pharmacokinetic data
Pregnancy Category: Not Recommended
Routes of Administration: By mouth
Bioavailability: Not Available
Protein Binding: Not Available
Metabolosim: Not Available
Onset of Action: Not Available
Elimination Half life: Not Available
Excretion: Not Available
Legal Status | Dosage forms & Strengths
Prescription Category:
Prescription only Medicine (POM) , â„ž-only
Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:
This drug is not a controlled substance under Narcotic Drugs and Psychotropic Substances (Control ) Act
Dosage Forms | Strengths:
Tablets
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Drug Images
References/ Citation:
Trukhacheva, L. A., et al. “Alkaline Hydrolysis Kinetics and No-Donor Activity of Tenonitrozole.” Pharmaceutical Chemistry Journal 39.6 (2005): 296-299.
Gadjiev, Z. I., and S. D. Demuxamedova. “Calculation of the IR spectrum of absorption of 2, 4, 6-tenonitrozole molecule; Raschet IK-spektra poglosheniya molekuli 2, 4, 6-trinitroanizola.” (2008).