Brands of Sulfamethoxypyridazine / Pyrimethamine in Kenya
MODE OF ACTION
It has a role as an antiinfective agent, an EC 184.108.40.206 (dihydropteroate synthase) inhibitor and a drug allergen. It is a member of pyridazines, a sulfonamide and a sulfonamide antibiotic. It derives from a sulfanilamide.
Pyrimethamine selectively inhibits the plasmodial form of dihydrofolate reductase, reducing the production of folic acid required for nucleic acid synthesis in the malarial parasite
Intermittent preventive treatment of malaria in pregnancy.
Therapy & prophylaxis of Malaria caused by P. faciparum; P. vivax; P.malariae and P. ovale.
DOSAGE AND ADMINISTRATION
Intermittent preventive treatment of malaria in pregnancy:
2 tabs once during the second trimester; 2 tablets once during the third trimester, last 2 weeks excluded ( for HIV –ve and HIV +ve women)
IPT should be given under Direct Observed Therapy (DOT) in the ante-natal clinic and can be given on an empty stomach.
considered to be safe for pregnancy between 16 – 36 weeks gestation. After 36 weeks it should be avoided due to the risk of kernicterus in new born.
Nausea; vomiting; leukopenia; purpura;
Over-dosage treatment: Gastric lavage & Forced diuresis.
Reporting of suspected adverse reactions:
The PPB Department of Pharmacovigilance was set up with a vision to develop, implement and continuously upgrade an appropriate system for detecting, reporting, and monitoring adverse drug reactions (ADRs) and other relevant problems with medicines in Kenya. The department strives to ensure the safety and efficacy of pharmaceutical products in Kenya.
Reporting suspected adverse reactions after authorization of the medicinal product are important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals/ Patients are encouraged to report any suspected adverse reactions via Pharmacovigilance Yellow Form, email@example.com or clicking below button:
Clinical | Pharmacokinetic data
Routes of Administration:
Onset of Action:
Elimination Half life:
Legal Status | Dosage forms & Strengths
Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:
Dosage Forms | Strengths: