Pharmacology & Brands Available:
Paracetamol Brands in Kenya
Abpara® , Abacus Pharma (A) Ltd
Ace®, Square Pharmaceuticals Ltd.
Acedol®,Square Pharmaceuticals Ltd.
Acemol®, Lab and Allied Ltd
Adco-napamol® , Adcock Ingram Ltd.
Adol®, Julphar Pharmaceutical industries
Asmol®, Astra Lifecare
Arcet® , Medisel Kenya Ltd
Arfen® , Medochemie Ltd
Axapara® , British Pharmaceuticals Limited
Betamol®, Sphinx Pharmaceuticals Ltd
Biomol®, Biodeal Laboratories Ltd
Blink Infusion®, Crown Healthcare
Calpol Infant®, GSK
Caremol® , Careplus Ltd
Cetamol®, Regal Pharmaceuticals Limite
Cipladon®, Cipla Ltd
Cosmol®, Cosmos Ltd
Curamol®, Dawa Ltd
Dentamol®, Lab and Allied
Efferalgan®, Bristol-Myers Squibb
Elymol®, Elys Chemical Industries Ltd
Fast® , ACME
Fremol®, Crown Healthcare
Feverex® , Beta Healthcare International Limited.
Ifimol® , Unique Pharmaceutical Laboratories
Infulgan®, Yuria Pharma Ltd
Junior Sonadol®, Orange Pharma Ltd
Kaldol® , Leben Laboratories Pvt Ltd
Lumidol® , Zawadi Healthcare Ltd
Micromol®, National Pharmacy Ltd
Napa®,Beximco Pharmaceuticals Ltd.
Neladol®, Universal Corporation Limited
PA 12®, Lincoln Pharmaceuticals Ltd
Painil®, Njimia (K) Limited
Panadol Advance® ,GSK
Panadol baby & Infant®, GSK
Panadol Actifast Soluble®,GSK
Parace® , Zest Pharma
Parafast ®, Highchem Marketing Limited
Parafil® , Fourrts (India) Laboratories Pvt. Limited
Paraflash®, Origens Limited
Paralab ®, Laborate Pharmaceuticals India Limited
Paralief® ,Sai Pharmaceuticals Limited
Paracetamol, Galpha Laboratories Ltd.
Paracetamol, Elys Chemical Industries Ltd
Paracetamol B.Braun, B.Braun Melsungen Ag
Paracetamol, United Pharma (K) Limited
Paracetamol Junior®, Elys Chemical Industries Ltd
Paradol®, Dinlas Pharma Epz Limited
Para-denk®, Denk Pharma GmbH & Co. KG
Paratal®, Lab & Allied Ltd
Parol® , Dafra Pharma GmbH
Pamol® , Comet Healthcare Limited
Perfalgan® , Bristol-Myers Squibb
Procet Infusion®, Makupa Chemist Limited
Prosia,® Kenpharma Healthcare Ltd
Pyremol® , Concepts (Africa) limited
Regamol® ,Orange Pharma Ltd
Reset® , Incepta Pharmaceuticals Ltd
Sanmol®, PT Sanbe Farma
Sheladol® , Shelys Pharmaceuticals Ltd.
Sonadol® , Orange Pharma Ltd
Thermodol® , Unosource Pharma Ltd
Topmol®, Axa Parenterals Ltd
Totomol®, Lab & Allied Ltd
Tylenol®, Johnson & Johnson
Ucetamol® , Umedica Laboratories Pvt Ltd
Woodwards Paracetamol Syrup® , Beta Healthcare International Limited.
Xykaa® , Troikaa Pharmaceuticals Limited
Zerover®, Kilitch Drugs (India) Ltd.
Paracetamol, a para-aminophenol derivative, has analgesic, antipyretic and weak anti-inflammatory activity. Paracetamol selectively inhibits cyclo-oxygenase enzyme in the brain and spinal cord thus reliefing pain and reducing fever without having unwanted gastro intestinal side effects. Paracetamol interfers with nerve conduction and is known to block impulse generations at bradykinin-sensitive chemoreceptors which evoke pain.
Paracetamol is readily absorbed from the gastro-intestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral doses. Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk. Plasma protein binding is negligible at usual therapeutic concentrations but increases with increasing concentrations. The elimination half-life of paracetamol varies from about 1 – 3 hours. Paracetamol is metabolised predominantly in the liver and excreted in the urine mainly as the glucuronide and sulfate conjugates.
DOSAGE AND ADMINISTRATION:
Doses to be given 3-4 times a day or as directed by the physician.
Paracetamol Suspension 120mg/5mL:
Children: 6 – 12 years: Half-one tablet or two-four spoonfuls (10-20mL).
1 – 6 years: One – two spoonfuls (5.0-10mL).
3 months – 1 year: Half – one spoonful (2.5-5mL).
Under 3 months: Not recommended.
Paracetamol Tablets 500mg
Adults and Children over 12 years:
One – two tablets 3-4 times a day.
Do not take more than 8 tablets in 24 hours.
Children should not be given doses of paracetamol Suspension more frequently than every 4 hours and not more than 4 doses should be given in any 24 hour period.
Paracetamol should be given with care to patients with impaired kidney or liver function. It should also be given with care to patients with alcohol dependence.
Adverse effects of Paracetamol are rare and usually mild, although haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Skin rashes, and other hypersensitivity reactions occur occasionally.
Overdosage with Paracetamol can result in severe liver damage and sometimes acute renal tubular necrosis.
Gastric lavage should be carried out especially if the overdose was taken within the previous hours; full supportive measures should also be instituted.
Activated charcoal is given to reduce gastro-intestinal absorption, especially in cases of multiple drug overdosage. However, if acetylcysteine or methionine is to be administered by mouth, the charcoal is best cleared from the stomach to prevent it reducing the absorption of the antidote.
The risk of Paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes. The absorption of paracetamol may be accelerated by drugs such as metoclopramide. Excretion may be affected and plasma concentrations altered when given with probenecid.