Vitamin E (alfa tocopherol)

Vitamin E in Kenya

MOA: The mechanism of action for most of vitamin E’s effects are still unknown. Vitamin E is an antioxidant, preventing free radical reactions with cell membranes.One mechanism of vitamin E’s antioxidant effect is in the termination of lipid peroxidation

Pharmacology & Brands Available:

Trade Names / Brands of Vitamin E in Kenya

Evit 200®, Geltec Private Limited (Vitamin E 200mg IU)

Evit 400® ,Geltec Private Limited (Vitamin E 400mg IU)

Enat 400®, Mega Lifesciences Ltd (Vitamin E 400mg IU)

E-Gel Soft Gelatin®, Renata Limited

Etovit®, USV Private Limited

Evion®, Cipla

Vitamin E is fat soluble (read: Vitamin A), so dietary supplement products are usually in the form of the vitamin dissolved in vegetable oil in a softgel capsule. For alpha-tocopherol, amounts range from 100 to 1000 IU per serving. Smaller amounts are incorporated into multi-vitamin/mineral tablets.

Vitamin E is a collective term used to describe 8 separate fat soluble antioxidants, most commonly alpha-tocopherol. Vitamin E acts to protect cells against the effects of free radicals, which are potentially damaging by-products of the body’s metabolism.All 8 separate fat soluble antioxidants  feature a chromane ring, with a hydroxyl group that can donate a hydrogen atom to reduce free radicals and a hydrophobic side chain which allows for penetration into biological membranes.

Vitamin E deficiency is seen in persons with abetalipoproteinemia, premature, very low birth weight infants (birth weights less than 1500 grams, or 3½ pounds), cystic fibrosis, and cholestasis and severe liver disease

Recommended Dietary Allowances (RDAs) for vitamin E in 2000

Indications

Vitamin E  may have a role in treating age-related macular degeneration , rheumatoid arthritis (painful joint disease), and tardive dyskinesia. Topical use of vitamin E has been investigated for the reduction of scarring.

Interactions

  • Orlistat may reduce vitamin E absorption.
  • Vitamin E may increase the anticoagulant effect of warfarin and may decrease the benefits of atorvastatin therapy.
  • Consumption of alpha-tocopherol as a dietary supplement in amounts in excess of 300 mg/day may lead to interactions with aspirin, tamoxifen and cyclosporine A in ways that alter function. For aspirin high amounts of vitamin E may potentiate anti-blood clotting action.

Side effects

Vitamin E when taken at high doses and for prolonged period may cause:

  • Nausea and vomiting.
  • Diarrhea.
  • Headache.
  • Rash.
  • Fatigue or weakness.
  • Blurry vision.