MOA: The mechanism of action for most of vitamin E’s effects are still unknown. Vitamin E is an antioxidant, preventing free radical reactions with cell membranes.One mechanism of vitamin E’s antioxidant effect is in the termination of lipid peroxidation
Pharmacology & Brands Available:
Trade Names / Brands of Vitamin E in Kenya
Evit 200®, Geltec Private Limited (Vitamin E 200mg IU)
Evit 400® ,Geltec Private Limited (Vitamin E 400mg IU)
Enat 400®, Mega Lifesciences Ltd (Vitamin E 400mg IU)
E-Gel Soft Gelatin®, Renata Limited
Etovit®, USV Private Limited
Vitamin E is fat soluble (read: Vitamin A), so dietary supplement products are usually in the form of the vitamin dissolved in vegetable oil in a softgel capsule. For alpha-tocopherol, amounts range from 100 to 1000 IU per serving. Smaller amounts are incorporated into multi-vitamin/mineral tablets.
Vitamin E is a collective term used to describe 8 separate fat soluble antioxidants, most commonly alpha-tocopherol. Vitamin E acts to protect cells against the effects of free radicals, which are potentially damaging by-products of the body’s metabolism.All 8 separate fat soluble antioxidants feature a chromane ring, with a hydroxyl group that can donate a hydrogen atom to reduce free radicals and a hydrophobic side chain which allows for penetration into biological membranes.
Vitamin E deficiency is seen in persons with abetalipoproteinemia, premature, very low birth weight infants (birth weights less than 1500 grams, or 3½ pounds), cystic fibrosis, and cholestasis and severe liver disease
Recommended Dietary Allowances (RDAs) for vitamin E in 2000
Vitamin E may have a role in treating age-related macular degeneration , rheumatoid arthritis (painful joint disease), and tardive dyskinesia. Topical use of vitamin E has been investigated for the reduction of scarring.
- Orlistat may reduce vitamin E absorption.
- Vitamin E may increase the anticoagulant effect of warfarin and may decrease the benefits of atorvastatin therapy.
- Consumption of alpha-tocopherol as a dietary supplement in amounts in excess of 300 mg/day may lead to interactions with aspirin, tamoxifen and cyclosporine A in ways that alter function. For aspirin high amounts of vitamin E may potentiate anti-blood clotting action.
Vitamin E when taken at high doses and for prolonged period may cause:
- Nausea and vomiting.
- Fatigue or weakness.
- Blurry vision.