MOA: The active vitamin D metabolite calcitriol mediates its biological effects by binding to the vitamin D receptor (VDR), which is principally located in the nuclei of target cells.The binding of calcitriol to the VDR allows the VDR to act as a transcription factor that modulates the gene expression of transport proteins (such as TRPV6 and calbindin), which are involved in calcium absorption in the intestine.VDR activation in the intestine, bone, kidney, and parathyroid gland cells leads to the maintenance of calcium and phosphorus levels in the blood (with the assistance of parathyroid hormone and calcitonin) and to the maintenance of bone content
Drug Label Information | Brands:
Brands of Vitamin D available in Kenya
VITA UV D3® 60000 IU, Galaxy Pharmaceutical Limited
Alphadol® 0.25 Mcg Capsules , Panacea Biotec Ltd. (Alfacalcidol Capsules 0.25 mcg)
Alphadol®-1 Mcg Capsules , Panacea Biotec Ltd. (Alfacalcidol Capsules 1.0 mcg)
JusDee 60K Granules® ,Stedman Pharmaceuticals Pvt. Ltd. (Colecalciferol BP 60,000 IU Excipients q.s.)
Alpha D3® ,Teva Pharmaceutical Industries
Arbivit-3®, Raptakos, Brett & Co. Ltd.
Meditrol® , Mega Life Science
Nicferol® Tablets, Nic Pharma (Cholecalciferol 2000 IU) (marketed by medisel)
Nicferol Forte® Tablets ,Nic Pharman (Cholecalciferol 60000 IU)
Several forms (vitamers) of vitamin D exist. The two major forms are vitamin D2 or ergocalciferol, and vitamin D3 or cholecalciferol; vitamin D without a subscript refers to either D2 or D3 or both. These are known collectively as calciferol
- Low levels of phosphate in the blood due to an inherited disorder called familial hypophosphatemia.
- Low levels of phosphate in the blood due to a disease called Fanconi syndrome.
- Low blood calcium levels due to low parathyroid hormone levels.
- Renal osteodystrophy
- Psoriasis (When applied topically)
Taking vitamin D and aluminum-containing phosphate binders long term might cause harmful levels of aluminum in people with kidney failure.
The anticonvulsants phenobarbital and phenytoin increase the breakdown of vitamin D and reduce calcium absorption.
High doses of vitamin D can cause hypercalcemia, which increases the risk of fatal heart problems with digoxin.