Tinidazole

Mechanism of Action of Tinidazole:
Tinidazole is an antiprotozoal, antibacterial agent. The nitro- group of tinidazole is reduced by cell extracts of Trichomonas. The free nitro- radical generated as a result of this reduction may be responsible for the antiprotozoal activity. Chemically reduced tinidazole was shown to release nitrites and cause damage to purified bacterial DNA in vitro. Additionally, the drug caused DNA base changes in bacterial cells and DNA strand breakage in mammalian cells. The mechanism by which tinidazole exhibits activity against Giardia and Entamoeba species is not known.

Drug Label Information | Brands:

Brands of Tinidazole in Kenya:

Amtiba®, Cadila pharm
Dawatin®, Dawa
Fasigyn®, Pfizer
Quadran®, Universal
Tidaz®, PSM
Tidazol® ,Elys Chemical Industries Ltd
Tina®, Bombay
Tini®,Lincoln Pharmaceuticals Ltd
Tiniba®, Zydus
Tinipro®, Cosmos
Tinidazole, Elys
Tinifred®, Fredun Pharmaceutical Ltd (for Crown Healthcare)
Tinimed®, Medico
Tinisky®, Pharma Life Science Limited
Tinizol®, Shalina
Tinda®,Opera Pharma (K) Ltd
Tinycos®, Cosmos Limited
Tizole®, Biodeal
Tricogyn®, Flamingo
Trinitab®, Cipla
Tynazole®, Lab and Allied
TZEX®, Syner-med
Wormazole®, Shelys

Indications For Tinidazole:

Trichomoniasis :The recommended dose in both females and males is a single 2 g oral dose taken with food

Giardiasis : The recommended dose in adults is a single 2 g dose taken with food

Amebiasis:

1. Intestinal -The recommended dose in adults is a 2 g dose per day for 3 days taken with food. In pediatric patients older than three years of age, the recommended dose is 50 mg/kg/day (up to 2 g per day) for 3 days with food.

2. Amebic Liver Abscess -The recommended dose in adults is a 2 g dose per day for 3-5 days taken with food. In pediatric patients older than three years of age, the recommended dose is 50 mg/kg/day (up to 2 g per day) for 3-5 days with food.

Bacterial Vaginosis: The recommended dose in non-pregnant females is a 2 g oral dose once daily for 2 days taken with food or a 1 g oral dose once daily for 5 days taken with food.

ContraIndications ®of Tinidazole:

The use of tinidazole is contraindicated:

  • In patients with a previous history of hypersensitivity to tinidazole or other nitroimidazole derivatives
  • During first trimester of pregnancy
  • In nursing mothers: Interruption of breast-feeding is recommended during tinidazole therapy and for 3 days following the last dose

Drug Interactions:

Tinidazole may enhance the effect of warfarin and other coumarin anticoagulants, resulting in a prolongation of prothrombin time.
Some products that may interact with this drug include: alcohol-containing products (such as cough and cold syrups, aftershave), products containing propylene glycol, lopinavir/ritonavir solution, lithium.

Adverse Effects of Tinidazole:

  • GI: Metallic/bitter taste
  • Nausea
  • Anorexia
  • Dyspepsia/cramps/epigastric discomfort
  • Vomiting
  • Constipation
  • CNS: Weakness/fatigue/malaise
  • Dizziness
  • Headache

Treatment Of Tinidazole Overdosage

There is no specific antidote for the treatment of overdosage with tinidazole; therefore, treatment should be symptomatic and supportive. Gastric lavage may be helpful.