Teicoplanin

Teicoplanin

Mode of Action of Teicoplanin

Teicoplanin inhibits the growth of susceptible organisms by interfering with cell-wall biosynthesis at a site different from that affected by beta-lactams. Peptidoglycan synthesis is blocked by specific binding to D-alanyl-D-alanine residues.

Drug Label Information | Brands:

Brands of Teicoplanin in Kenya

Targocid®, Sanofi-aventis Kenya

Ticplat® ,Gufic Stridden Biopharma Private Ltd.

INDICATIONS:

Targocid is indicated in adults and in children from birth for the parenteral treatment of the following infections

  • complicated skin and soft tissue infections,
  • bone and joint infections,
  • hospital acquired pneumonia,
  • community acquired pneumonia,
  • complicated urinary tract infections,
  • infective endocarditis,
  • peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD),
  • bacteraemia that occurs in association with any of the indications listed above.

Teicoplanin is also indicated as an alternative oral treatment for Clostridium difficile infection-associated diarrhoea and colitis.

Where appropriate, teicoplanin should be administered in combination with other antibacterial agents.

CONTRAINDICATIONS:

Hypersensitivity to teicoplanin or to any of the excipients

ADVERSE DRUG INTERACTIONS:

Infections and infestations

Abscess

Superinfection (overgrowth of non-susceptible organisms)

Blood and the lymphatic system disorders

Leucopenia, thrombocytopenia, eosinophilia

Agranulocytosis, neutropenia

Immune system disorders

Anaphylactic reaction (anaphylaxis)

Drug reaction with eosinophilia and systemic symptoms (DRESS), anaphylactic shock

Nervous system disorders

Dizziness, headache

Seizures

Ear and Labyrinth disordersDeafness, hearing loss , tinnitus, vestibular disorder

Vascular disorders

Phlebitis

Thrombophlebitis

Respiratory, thoracic and mediastinal disorders

Bronchospasm

Gastro-intestinal disorders

Diarrhoea, vomiting, nausea

Skin and subcutaneous tissue disorders

Rash, erythema, pruritus

Red man syndrome (e.g. Flushing of the upper part of the body)

Toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, angioedema, dermatitis exfoliative, urticaria

Renal and Urinary disorders

Blood creatinine increased