Streptomycin

Streptomycin chemical Structure: Streptomycin in Kenya

Mechanism of Action:

Streptomycin is a protein synthesis inhibitor. It binds to the small 16S rRNA of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit.

Drug Label Information | Brands:

Brands of Streptomycin In Kenya:

Carestrep , Careplus Limited
Strepto 1, Crown Healthcare
Streptomycin, Dawa
Streptomycin , Macleods Pharmaceuticals Limited

INDICATIONS:

a) Mycobacterium tuberculosis:

b) Non-tuberculosis infections:

Pasteurella pestis (plague),
Francisella tularensis (tularemia),
Brucella
Calymmatobacterium granulomatis (donovanosis, granuloma inguinale)
H. ducreyi (chancroid),
H. influenzae (in respiratory, endocardial, and meningeal infections-concomitantly with another antibacterial agent),
K. pneumoniae pneumonia (concomitantly with another antibacterial agent).
E.coli, Proteus, A. aerogenes, K. pneumoniae, and Enterococcus faecalis in urinary tract infections.
Streptococcus viridans, Enterococcus faecalis (in endocardial infections -concomitantly with penicillin)
Gram-negative bacillary bacteremia (concomitantly with another antibacterial agent).

CONTRAINDICATIONS:

A history of clinically significant hypersensitivity to streptomycin is a contraindication to its use. Clinically significant hypersensitivity to other aminoglycosides may contraindicate the use of streptomycin because of the known cross-sensitivity of patients to drugs in this class.

ADVERSE REACTIONS:

The following reactions are common: vestibular ototoxicity (nausea, vomiting, and vertigo); paresthesia of face; rash; fever; urticaria; angioneurotic edema; and eosinophilia.

The following reactions are less frequent: cochlear ototoxicity (deafness); exfoliative dermatitis; anaphylaxis; azotemia; leucopenia; thrombocytopenia; pancytopenia; hemolytic anemia; muscular weakness; and amblyopia.

DRUG INTERACTIONS:

The ototoxic effects of the aminoglycosides, including streptomycin, are potentiated by the co-administration of ethacrynic acid, furosemide, mannitol and possibly other diuretics.