Sodium Fusidate

Sodium Fusidate in Kenya

Mode of Action:

Fusidic acid inhibits bacterial protein synthesis by interfering with amino acid transfer from aminoacyl-tRNA to protein on the ribosomes.

Drug Label Information | Brands:

Fucidin, LEO Pharma A/S

INDICATIONS:

Sodium Fusidate is indicated in the treatment of all staphylococcal infections due to susceptible organisms such as: cutaneous infections, osteomyelitis, pneumonia, septicaemia, wound infections, endocarditis, superinfected cystic fibrosis.

Sodium Fusidate should be administered intravenously whenever oral therapy is inappropriate, which includes cases where absorption from the gastro-intestinal tract is unpredictable.

ADMINISTRATION:

For staphylococcal cutaneous infections:

Adults:

Standard dose: 250 mg sodium fusidate (equivalent to 240 mg fusidic acid) twice daily for 5-10 days.

For staphylococcal infections such as osteomyelitis, pneumonia, septicaemia, wound infections, endocarditis, superinfected cystic fibrosis.

Adults:

Standard dose: 500 mg sodium fusidate (equivalent to 480 mg fusidic acid) 3 times daily.

In severe cases of fulminating infections, the dosage may be doubled or appropriate combined therapy may be used.

Elderly: No dosage alterations are necessary in the elderly.

Since Sodium Fusidate is excreted in the bile, no dosage modifications are needed in renal impairment.

The dosage in patients undergoing haemodialysis needs no adjustment as Sodium Fusidate is not significantly dialysed.

 

DRUG INTERACTIONS

  • Systemic Sodium Fusidate administered concomitantly with oral anticoagulants such as coumarin derivatives or anticoagulants with similar actions may increase the plasma concentration of these agents enhancing the anticoagulant effect.
  • The risk of myopathy including rhabdomyolysis may be increased by the concomitant administration of systemic Sodium Fusidate with statins. Co-administration of this combination may cause increased plasma concentrations of both agents.
  • Co-administration of systemic Sodium Fusidate and HIV protease inhibitors such as ritonavir and saquinavir may cause increased plasma concentrations of both agents which may result in hepatotoxicity.

ADVERSE DRUG REACTIONS:

The most frequently reported undesirable effects of Sodium Fusidate administered orally are gastrointestinal disorders like abdominal discomfort and pain, diarrhoea, dyspepsia, nausea and vomiting. Anaphylactic shock has been reported.

You can get Sodium fusidate Tablets,Cream or ointment in Registered  Pharmacy new You