Paracetamol /Caffeine

Brands of Paracetamol /Caffeine in Kenya

Curamol plus, Dawa Limited

Napa Extra , Beximco Pharmaceuticals Ltd.

Painotab , Cosmos Limited

Panadol Extra, GSK

Panadol Extra with Optizorb, GlaxoSmithKline Kenya Limited

Sonamol Extra, Orange Pharma Ltd

Sonadol Extra , Orange Pharma Ltd


Caffeine in Kenya: Chemical Structure,Prices, Brands
Caffeine Chemical Structure
Paracetamol Chemical Structure : Paracetamol Brands in Kenya
Paracetamol Chemical Structure

MODE OF ACTION:

The combination of paracetamol and caffeine is a well established analgesic combination.

INDICATIONS

This is recommended for the treatment of most painful and febrile conditions, for example, headache, including migraine, backache, toothache, rheumatic pain and dysmenorrhoea, and relief of the symptoms of colds, influenza and sore throat.

CONTRAINDICATIONS

Hypersensitivity to paracetamol, caffeine or any of the other constituents.

The speed of absorption of paracetamol may be increased by metoclopramide or domperidone and absorption reduced by colestyramine. The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.

DRUG INTERACTIONS:

The speed of absorption of paracetamol may be increased by metoclopramide or domperidone and absorption reduced by colestyramine. The anticoagulant effect of warfarin and other coumarins may be enhanced b

ADVERSE EFFECTS:

Blood and lymphatic system disorders

Thrombocytopenia Agranulocytosis

Immune system disorders

Anaphylaxis

Cutaneous hypersensitivity reactions including skin rashes, angiodema and Stevens Johnson syndrome/toxic epidermal necrolysis

Respiratory, thoracic and mediastinal disorders

Bromchospasm*

Hepatobiliary disorders

Hepatic dysfunction

* There have been cases of bronchospasm with paracetamol, but these are more likely in asthmatics sensitive to aspirin or other NSAIDs.

Caffeine

Central Nervous system

Nervousness Dizziness

When the recommended paracetamol-caffeine dosing regimen is combined with dietary caffeine intake, the resulting higher dose of caffeine may increase the potential for caffeine-related adverse effects such as insomnia, restlessness, anxiety, irritability, headaches, gastrointestinal disturbances and palpitations.

Clinical | Pharmacokinetic data


Pregnancy Category: Paracetamol-caffeine is not recommended for use during pregnancy due to the possible increased risk of lower birth weight and spontaneous abortion associated with caffeine consumption.
Routes of Administration: Oral
Bioavailability: Not Available
Protein Binding: Not Available
Metabolosim: Not Available
Onset of Action: Not Available
Elimination Half life: Not Available
Excretion: Not Available

Legal Status | Dosage forms & Strengths


Prescription Category:
OTC / Rx-only
Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:
This drug is not a controlled substance under Narcotic Drugs and Psychotropic Substances (Control ) Act
Dosage Forms | Strengths:


Drug Indentifiers:

Paracetamol:

CAS Number
PubChem CID
PubChem SID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard

Caffeine:

CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard


Drug Images

References/ Citation:

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