Brands of Paracetamol /Caffeine in Kenya
Curamol plus, Dawa Limited
Napa Extra , Beximco Pharmaceuticals Ltd.
Painotab , Cosmos Limited
Panadol Extra, GSK
Panadol Extra with Optizorb, GlaxoSmithKline Kenya Limited
Sonamol Extra, Orange Pharma Ltd
Sonadol Extra , Orange Pharma Ltd
MODE OF ACTION:
The combination of paracetamol and caffeine is a well established analgesic combination.
This is recommended for the treatment of most painful and febrile conditions, for example, headache, including migraine, backache, toothache, rheumatic pain and dysmenorrhoea, and relief of the symptoms of colds, influenza and sore throat.
Hypersensitivity to paracetamol, caffeine or any of the other constituents.
The speed of absorption of paracetamol may be increased by metoclopramide or domperidone and absorption reduced by colestyramine. The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.
The speed of absorption of paracetamol may be increased by metoclopramide or domperidone and absorption reduced by colestyramine. The anticoagulant effect of warfarin and other coumarins may be enhanced b
Blood and lymphatic system disorders
Immune system disorders
Cutaneous hypersensitivity reactions including skin rashes, angiodema and Stevens Johnson syndrome/toxic epidermal necrolysis
Respiratory, thoracic and mediastinal disorders
* There have been cases of bronchospasm with paracetamol, but these are more likely in asthmatics sensitive to aspirin or other NSAIDs.
Central Nervous system
When the recommended paracetamol-caffeine dosing regimen is combined with dietary caffeine intake, the resulting higher dose of caffeine may increase the potential for caffeine-related adverse effects such as insomnia, restlessness, anxiety, irritability, headaches, gastrointestinal disturbances and palpitations.
Clinical | Pharmacokinetic data
Pregnancy Category: Paracetamol-caffeine is not recommended for use during pregnancy due to the possible increased risk of lower birth weight and spontaneous abortion associated with caffeine consumption.
Routes of Administration: Oral
Bioavailability: Not Available
Protein Binding: Not Available
Metabolosim: Not Available
Onset of Action: Not Available
Elimination Half life: Not Available
Excretion: Not Available
Legal Status | Dosage forms & Strengths
OTC / Rx-only
Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:
This drug is not a controlled substance under Narcotic Drugs and Psychotropic Substances (Control ) Act
Dosage Forms | Strengths:
|CompTox Dashboard (EPA)|
|CompTox Dashboard (EPA)|
- Wojcicki, J., et al. “A double-blind comparative evaluation of aspirin, paracetamol and paracetamol+ caffeine (finimal) for their analgesic effectiveness.” Archivum immunologiae et therapiae experimentalis 25.2 (1977): 175.
- Esmaoglu, Aliye, Hatice Akpinar, and Fatih Uğur. “Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache.” Journal of clinical anesthesia 17.1 (2005): 58-61.