MOA: Nitrofurans interfere with cell metabolism and cell wall synthesis by inhibiting several enzyme systems including Acetyl Coenzyme A
Pharmacology & Brands Available:
Brands of Nitrofurantoin in Kenya:
Nifuran®, Lab and Allied
Indications / Dosage
Treatment of uncomplicated urinary tract infections (UTIs) and prophylaxis against UTIs in people prone to recurrent UTIs.It is effective against E. Coli, Enterobacter cystitis, Enterococcus, Klebsiella, and Staphylococcus aureus.
Adults and Pediatric Patients Over 12 Years: 100 mg every 12 hours for seven days.
- Hypersensitivity to nitrofurantoin
- Renal Disorders
Antacids that contain magnesium trisilicate: These drugs can make nitrofurantoin less effective
Probenecid and sulfinpyrazone: Taking these drugs while you’re taking nitrofurantoin may cause harmful levels of nitrofurantoin to build up in your blood.
Side Effects of NitroFurantoin:
nausea, loss of appetite, diarrhoea, and headaches
Rarely numbness, lung problems, or liver problems may occur