Nifuroxazide

Brands of  Nifuroxazide in Kenya

Ercefuryl®, Sanofi-aventis Kenya


Nifuroxazide in Kenya : Price, Brand names, Generics, Uses, Side effects
Nifuroxazide Chemical Structure

Nifuroxazide Mode of Action:

Nifuroxazide inhibits the constitutive phosphorylation of STAT3 in MM cells by reducing Jak kinase autophosphorylation, and leads to down-regulation of the STAT3 target gene Mcl-1.

INDICATIONS

Nifuroxazide belongs to the group of the intestinal anti-infective drugs. It is available as an over the counter medication for the treatment of acute diarrhea if it is caused by bacteria. Studies have shown that this medication reduces the number of stools after only two days of treatment and reduces the duration of diarrhea for around twenty four hours. Nifuroxazide does not affect the intestinal flora

DOSAGE AND ADMINISTRATION

The usual dose for children aged 6-18 years is 200 mg three times a day. In adult patients, the recommended dose is 200 mg four times a day. Duration of therapy should not be longer than seven days.
In children aged 2-6 years Nifuroxazide should be taken as oral suspension 200 mg / 5 ml. Recommended dose is 5 ml three times a day. Use of this drug in children younger than 2 years is not recommended.
This drug can be taken regardless of meals.

CONTRAINDICATIONS / PRECAUTIONS:

Contraindication to the use of the Nifuroxazide is hypersensitivity to this substance.
Nifuroxazide should not be taken in the following situations:

  • If you have bloody stools
  • If you have a fever
  • If you are vomiting

DRUG INTERACTIONS:

Nifuroxazide should not be administered concomitantly with following drugs:

  • Metronidazole (a drug used in the treatment of anaerobic infections and infections caused by parasites)
  • Sulfonamides (e.g. Bactrim), which is mainly used to treat urinary tract infections
  • Cephalosporins (antibiotics)
  • Chloramphenicol
  • Nitrofurantoin (a drug used to treat urinary tract infections)
  • Griseofulvin – a drug used in the treatment of fungal infections

Nifuroxazide should never be administered in combination with the above mentioned drugs as this increases the risk of disulfiram-like reaction, which is characterized by: severe nausea and vomiting, headache and rapid heartbeat.
Also, this drug should not be administered simultaneously with sedatives (e.g. benzodiazepines, such as: bromazepam, alprazolam, lorazepam, midazolam and others).

ADVERSE DRUG REACTIONS:

Nifuroxazide may cause the following side effects:

  • Quincke’s edema (angioneurotic edema which includes subcutaneous tissue and is characterized by allergic reaction)
  • Urticaria
  • Anaphylactic shock
Reporting of suspected adverse reactions:

The PPB Department of Pharmacovigilance was set up with a vision to develop, implement and continuously upgrade an appropriate system for detecting, reporting, and monitoring adverse drug reactions (ADRs) and other relevant problems with medicines in Kenya. The department strives to ensure the safety and efficacy of pharmaceutical products in Kenya.
Reporting suspected adverse reactions after authorization of the medicinal product are important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals/ Patients are encouraged to report any suspected adverse reactions via Pharmacovigilance Yellow Form, pv@pharmacyboardkenya.org or clicking below button:


Nifuroxazide in Kenya
Nifuroxazide in Kenya
Nifuroxazide in Kenya
Nifuroxazide in Kenya
Nifuroxazide in Kenya

Clinical | Pharmacokinetic data


Pregnancy Category: Not available
Routes of Administration: Oral
Bioavailability: Not Available
Protein Binding: Not Available
Metabolosim: Not Available
Onset of Action: Not Available
Elimination Half life: Not Available
Excretion: Not Available

Legal Status | Dosage forms & Strengths


Prescription Category:
Prescription only Medicine (POM) , ℞-only
Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:
This drug is not a controlled substance under Narcotic Drugs and Psychotropic Substances (Control ) Act
Dosage Forms | Strengths:
Capsules | Suspension

Drug Indentifiers:

CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard


Drug Images

References/ Citation:




What was the patient being treated for
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