Metronidazole

MOA: Metronidazole is of the nitroimidazole class. It inhibits nucleic acid synthesis by disrupting the DNA of microbial cells.This function only occurs when metronidazole is partially reduced, and because this reduction usually happens only in anaerobic bacteria and protozoans, it has relatively little effect upon human cells or aerobic bacteria

Drug Label Information | Brands:

Brands of Metronidazole in Kenya:

Abagyl®, Abacus Pharma (A) Limited
Axagyl Injection®, British Pharmaceuticals Limited
Amebazole®, Sphinx Pharmaceuticals Ltd
Amebil®, Njimia (K) Limited
Amizole®, Biopharma
Astrogyl®, Astra Lifecare
Biozole®,Sanofi
Calzole®, Concepts
Dangyl®, Dinlas Pharma Epz Limited
Elogyl®, Elys Chemical Industries Ltd
Eflaron®, Dawa Limited
Farcozol®, Pharco
Filmet®, Beximco Pharmaceuticals Ltd.
Flagimed®, Medivet
Flagilite Suspension®, Skylight Chemical Industries
Flagyl®, Sanofi-aventis Kenya
Flagyl viaflex®, Sanofi (Infusion)
Flazole®, Comet Healthcare Limited
Gestazole®, Gesto
Labzole® ,Laborate Pharmaceuticals India Limited
Medizole®, medipharm
Medzole®, Careplus Ltd
Megyl®, Regal Pharmaceuticals Limited
Metlife®, Aiveen Kenya Ltd
Metris®, Claris Otsuka Private Limited
Metrogyl®, Unique Pharmaceutical Laboratories
Metronidazole ,Aishwarya Lifesciences
Metronidazole, Marck
Metronidazole, Piramol
Metronidazole ,Amanta Healthcare Limited C/o Surgilinks Ltd
Metronidazole , Medopharm C/o Medox Pharmaceuticals Ltd
Metronidazole, United Pharma (K) Limited
Metronyl®, Mac’s
Metrowin®, Medisel Kenya Ltd
Metrozine®, The Searle Company Limited
Metrozol®, Cosmos Limited
Nelzole®, Universal Corporation Limited
Nidagyl®, Oss-Chemie
Nirmet®, Aculife Healthcare Pvt Ltd
Shelgyl®, Shelys Pharmaceuticals Ltd.
Trichazole®, Fresenius Kabi Manufacturing SA (Pty) Limited
Trichogyl®, Tablets India
Tricozole®, Lab and Allied
Trichogyl®, Tablets
Trogyl®, Biodeal Laboratories Ltd
Troz®, Zawadi Healthcare Ltd
Unizole®, PMC
Wescogyl®, West Coast
Zagole®, GSK
Zenogyl®, Zenufa

Indications:

Bacterial vaginosis
Drugs of choice for the treatment of bacterial vaginosis include metronidazole and clindamycin. The treatment of choice for bacterial vaginosis in nonpregnant women include metronidazole oral twice daily for seven days, or metronidazole gel intravaginally once daily for five days, or clindamycin intravaginally at bedtime for seven days. For pregnant women, the treatment of choice is metronidazole oral three times a day for seven days. Data does not report routine treatment of male sexual partner

Trichomoniasis
The 5-nitroimidazole drugs (metronidazole and tinidazole) are the mainstay of treatment for infection with Trichomonas vaginalis. Treatment for both the infected patient and the patient’s sexual partner is recommended, even if asymptomatic.

Giardiasis
Oral metronidazole is a treatment option for giardiasis, however, the increasing incidence of nitroimidazole resistance is leading to the increased use of other compound classes

Dracunculus
In the case of Dracunculus (guinea worm), metronidazole just eases worm extraction rather than killing the worm.

C. difficile colitis
Initial antibiotic therapy for less-severe Clostridium difficile colitis (pseudomembranous colitis) consists of metronidazole, vancomycin, or fidaxomicin by mouth
Vancomycin by mouth has been shown to be more effective in treating people with severe C. difficile colitis

E. histolytica :
Entamoeba histolytica invasive amebiasis is treated with metronidazole for eradication, in combination with diloxanide to prevent recurrence

Contraindications:

Pregnancy and lactation, blood dyscrasia, CNS disturbances

Drug Interactions:

Warfarin: Anticoagulant effect is enhanced

Side Effects:

GI discomfort, nausea, diarrhea, weight loss ,headache, dizziness, and metallic taste in the mouth
Infrequent adverse effects include: hypersensitivity reactions (rash, itch, flushing, fever), headache, dizziness, vomiting, glossitis, stomatitis, dark urine, and paraesthesia