levofloxacin

Levofloxacin Chemical Structure: Levofloxacin in Kenya, Prices

MOA: It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV,enzymes necessary to separate bacterial DNA, thereby inhibiting cell division

Drug Label Information | Brands:

Brands/ Trade names of Levofloxacin in Kenya

Ablevox®, Abacus Pharma (A) Limited
Agio-Levo®, Agio Pharmaceuticals Ltd
Axalevo Infusio®n, British Pharmaceuticals Limited
Evo 500®, Beximco Pharmaceuticals Ltd.
Evonex®, Jayson Pharmaceutical Ltd.
Flovanis®, Opsonin
Gen Levo®, Brookes Pharmaceutical Laboratories Ltd
Glevonix®, Glenmark Pharmaceuticals Limited
Glevonix IV®, Glenmark Pharmaceuticals Limited
L-Bac®, Popular Pharmaceuticals Ltd
Leflocin® , Yuria Pharma LTD
Leeflox®, Centaur Pharmaceuticals Pvt. Ltd.
Leflox®,Getz Pharma (Pvt) Limited
Leflox IV®, Getz Pharma (Pvt) Limited
Levin®, Hetero Labs Limited
Levo®,Ferozsons
Levo-G®,Gracure Pharmaceuticals Ltd
Levo-Denk®, Denk Pharma GmbH & Co. KG
Levobact®, Micro Labs Limited India
Levocin®, PT Sanbe Farma
Levocil®, CCL Pharmaceutical (Pvt) Ltd.
Levoday®, Zydus Cadila Healthcare Limited
Levodon®, Cipla Ltd
Levodon IV®, Cipla Ltd
Levoflacin®, Flamingo
Levogol®, Zawadi Healthcare Ltd
Levokop®, Kopran Limited
Levomac®, Macleods Pharmaceuticals Limited
Levomax®, Eskayef Bangladesh Ltd.
Levomed, Aglowmed Limited
Levopro®, PSM Pharmaceuticals Ltd
Levostand® , Mankind Pharma Ltd
Levotil®, Nextgen Pharmaceuticals (K) Ltd.
Levotop® , Ajanta Pharma Limited
Levotop IV®, Ajanta Pharma Limited
Levoz®, Beta
Levoquin®, Navana
levox®, Cipla
Levoxcin®, Dawa Limited
Levoz®, Shelys Pharmaceuticals Ltd.
Lexx®, Metro
Lifcin®, Biopharma
Livota®,Zawadi Healthcare Ltd
Lotor®, Emcure Pharmaceuticals Ltd.
Loxof®, Ranbaxy
Marklevo®, Marksans
Mlevo® , National Pharmacy Limited
MYDAWA Levofloxacin® ,Mydawa Trading Limited
Nirliv®, Aculife Healthcare Pvt Ltd
Oraflox®, Deutsche
Safelevo®, MSN Laboratories Private Limited
Safloxa® , Krishna Chemists Ltd
Spectrix®, Pharmevo
Tavanic®, Sanofi-aventis Kenya
Trevox®, Square
Utivanic®, Signature Healthcare Ltd
Uvex®, Meyer Organic Pvt Ltd
Vofax®, Crown Healthcare
Welquine® ,Unosource Pharma Limited
Zlevo Tablets®, Shambhuprasad and Sons
Zolevox®, Innocia Lifesciences Pvt. Ltd.

Levofloxacin is used to treat infections including respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, endocarditis, meningitis, pelvic inflammatory disease, traveller’s diarrhoea, tuberculosis, and plague and is available by mouth, intravenously, and an eye drop form

ADVERSE DRUG REACTIONS

  • nausea,
  • vomiting,
  • diarrhoea,
  • headache,
  • constipation,
  • difficulty sleeping (insomnia),
  • dizziness,
  • abdominal pain,
  • rash,
  • abdominal gas,
  • itching, and
  • vaginal itching or discharge.

Levofloxacin has been associated with tendinitis and tendon rupture. Levofloxacin can alter the normal bacteria in the colon and cause pseudomembranous colitis. Patients taking Levofloxacin can develop photosensitivity (sensitivity to sunlight) and patients may sunburn more easily.

Drug interactions:

A)Effect of other medicinal products .

i) iron salts, zinc salts, magnesium~ or Aluminium containing antacids. didanosine

Levofloxacin absorption is significantly reduced when iron salts, or magnesium or aluminium-containing antacids, are administered concomitantly.

Concurrent administration with multi-vitamins containing zinc appears to reduce their oral absorption.

calcium salts have a minimal-effect on the oral absorption of Levofloxacin

ii) Sucralfate
The bioavailability is significantly reduced when administered together with sucralfate.

iii) Theophylline,non-steroidal anti-inflammatory drugs
A pronounced lowering of the cerebral seizure threshold may occur when quinolones are given concurrently with theophylline, non-steroidal anti-inflammatory drugs, or other agents which . lower the seizure threshold.

iv) Probenecid and Cimetidine

Probenecid and Cimetidine had a statistically significant effect on the elimination of Levofloxacin

Caution should be exercised when Levofloxacin is co-administered with drugs that affect the tubular renal secretion such as Probenecid and Cimetidine, especially in renally impaired patients.

B) Effect on other medicinal products

i) Cyclosporine
The half-life of Cyclosporine was increased by 33% when co-administered with Levofloxacin

ii) Vitamin K antagonists

Increased coagulation tests and/or bleeding, which may be severe, have been reported in patients treated with Levofloxacin in combination with a vitamin K antagonist (e.g Warfarin)

Coagulation tests, therefore, should be monitored in patients treated with vitamin K antagonists.

iii) Drugs known to prolong QT interval.

Levofloxacin should be used with caution in patients receiving drugs known to prolong the QT interval (eg. Class IA and III antiarrhythmics, tricyclic antidepressants, macrolide and antipsychotics)