Kanamycin A

Mechanism of Action:
Kanamycin works by interfering with protein synthesis. It binds to the 30S subunit of the bacterial ribosome. This results in incorrect alignment with the mRNA and eventually leads to a misread that causes the wrong amino acid to be placed into the peptide.


Brands of Kanamycin in Kenya:

Dawa-cin®, Dawa
Kanamed , Medisel Kenya Ltd
Kanamycin is a mixture of three main components: kanamycin A, B, and C. Kanamycin A is the major component in kanamycin
Kanamycin was first isolated in 1957 by Hamao Umezawa from the bacterium Streptomyces kanamyceticus

INDICATIONS:

Kanamycin is indicated for short term treatment of bacterial infections caused by one or more of the following pathogens: E. coli, Proteus species (both indole-positive and indole-negative), Enterobacter aerogenes, Klebsiella pneumoniae, Serratia marcescens, and Acinetobacter species. In cases of serious infection when the causative organism is unknown, Kanamycin injection in conjunction with a penicillin– or cephalosporin-type drug may be given initially before obtaining results of susceptibility testing.
Kanamycin does not treat viral infections

CONTRAINDICATIONS:

Documented hypersensitivity

SIDE EFFECTS:

Serious side effects include ringing in the ears or loss of hearing, toxicity to kidneys, and allergic reactions to the drug.
Other side effects include:
Gastrointestinal effects
Nausea, vomiting, diarrhea
Musculoskeletal effects
Myasthenia gravis
Neurologic effects
Headache
Paresthesias
Blurring of vision
Neuromuscular blockade
Metabolic effects
Malabsorption syndrome

Clinical | Pharmacokinetic data


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Legal Status | Dosage forms & Strengths


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Drug Images

References/ Citation:

Kanamycin