Mode of Action of Diloxanide :
Luminal amebicide.The mechanism of action of diloxanide is unknown.This agent destroys the trophozoites of E. histolytica that eventually form into cysts. The cysts are then excreted by persons infected with asymptomatic amebiasis.
Brands of Diloxanide in Kenya:
Diloxanide® , Cosmos limited
Diloxate®, Dawa Limited
For the treatment of acute and chronic intestinal amoebiasis.
Dosage and administration:
For oral use.
Adults: One 500mg tablet three times daily for ten days.
Elderly: There is no need for dosage reduction in the elderly.
Children: 20 mg/kg bodyweight daily in divided doses for ten days. Diloxanide is not suitable for use in children weighing less than 25 kg.
Hypersensitivity to diloxanide furoate.
Precautions and warnings:
Keep all medicines out of the reach of children.
No clinically significant drug interactions known. Pregnancy and lactation: Contraindicated in pregnancy and lactation.
Clinical | Pharmacokinetic data
Routes of Administration: By mouth
Protein Binding: Not Available
Metabolosim: Hydrolyzed to furoic acid and diloxanide, which undergoes extensive glucuronidation
Onset of Action:
Elimination Half life: 3 hours
Excretion: Kidney (90%), fecal (10%)
Legal Status | Dosage forms & Strengths
Prescription only Medicine (POM) , ℞-only
Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:
This Drug is not Subject to DDA drugs Act
Dosage Forms | Strengths:
Tablets | Syrup
|CompTox Dashboard (EPA)|
- PPB Retention Register
- World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 179, 587. hdl:10665/44053. ISBN 9789241547659.
- Arcangelo, Virginia Poole (2006). Pharmacotherapeutics For Advanced Practice: A Practical Approach. Lippincott Williams and Wilkins. pp. 441. ISBN 978-0-7817-5784-3.