Diclofenac /Paracetamol /Serratiopeptidase

Brands of Diclofenac /Paracetamol /Serratiopeptidase in Kenya

Enzoflam® , Alkem Laboratories

Lysoflam® ,Cachet Pharmaceuticals Pvt. Ltd

Mode Of Action:

This is a combination of three drugs Diclofenac, Paracetamol, and Serratiopeptidase

Diclofenac has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of Diclofenac, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro.

Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors.

Serratiopeptidase reduces pain and swelling without inhibiting prostaglandins and has no gastrointestinal adverse effects. It also acts by enhancing blood circulation due to proteolytic effect, removing damaged and denatured proteins and cellular debris, and modulating inflammatory cytokines.

Diclofenac paracetamol and serratiopeptidase combined together to provide effective relief from pain and inflammation.


Acute painful & inflammatory conditions

Dosage and Administration

Adults and children (12years and over)

One tablet twice daily.


Diclofenac is contraindicated in patients with peptic ulcers, asthma. Paracetamol is contraindicated in patients with hepatic dysfunction.

Warnings and Precautions

Risk of GI ulceration, bleeding, and perforation with NSAID therapy

Severe GI toxicity such as bleeding, ulceration, and perforation, can occur at any time with or without any warning
Symptoms, in patients, treated chronically-with NSAIDs Caution should be exercised when administering Diclofenac chronically.

Advanced renal disease

Close monitoring of renal parameters in such patients is advisable.


The use of this drug should be avoided unless the potential therapeutic benefits justify its use during pregnancy.


It should be administered to lactating women only if potential benefits justify the risks to the infant.


The drug should be used With caution in patients With peptic ulcer disease, gastrointestinal perforation, and bleeding. Paracetamol should be used with caution in patients with anemia.

Side Effects

Nausea. vomiting. dyspepsia, skin rashes, and hepatic disturbances.

Reporting of suspected adverse reactions:

The PPB Department of Pharmacovigilance was set up with a vision to develop, implement and continuously upgrade an appropriate system for detecting, reporting and monitoring adverse drug reactions (ADRs) and other relevant problems with medicines in Kenya. The department strives to ensure the safety and efficacy of pharmaceutical products in Kenya.
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals/ Patients are encouraged to report any suspected adverse reactions via Pharmacovigilance Yellow Form, pv@pharmacyboardkenya.org or clicking below button:


Following an acute overdosage, toxicity may result. Symptoms Include gastrointestinal irritation with erosion and hemorrhage or perforation, kidney damage, liver damage, heart damage. hemolytic anemia, agranulocytosis, thrombocytopenia, aplastic anemia. and meningitis. Other symptoms may include headache, dizziness. tinnitus, confusion. blurred vision, mental disturbances, skin rash. stomatitis, edema, reduced retinal sensitivity. corneal deposits. and hyperkalemia.

Diclofenac /Paracetamol /Serratiopeptidase in Kenya
Diclofenac /Paracetamol /Serratiopeptidase in Kenya
Diclofenac /Paracetamol /Serratiopeptidase in Kenya
Diclofenac /Paracetamol /Serratiopeptidase in Kenya
Diclofenac /Paracetamol /Serratiopeptidase in Kenya
Lysoflam in Kenya
Lysoflam in Kenya
Price of Lysoflam in Kenya
Cost of Lysoflam in Kenya
Availability of Enzoflam in Kenya
Price of Enzoflam in Kenya
Cost of Enzoflam in Kenya
How much does Enzoflam cost in Kenya
Enzoflam in Kenya

Clinical | Pharmacokinetic data

Pregnancy Category:
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Protein Binding:
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Legal Status | Dosage forms & Strengths

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Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:

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Drug Images

References/ Citation:

What was the patient being treated for