Dexpanthenol / Polyvinyl Alcohol Eye Drops

Brands of Dexpanthenol / Polyvinyl Alcohol Eye Drops in Kenya

Siccaprotect Eye Drops , Ursapharm Arzneimittel Gmbh

COMPOSITION

The active substances are dexpanthenol 30 mg, polyvinyl alcohol 14 mg in 1 ml (about 30 drops) eye drops.

MODE OF ACTION

Dexpanthenol has been shown to interact with lipid segments of the extracellular lamellae and protein residues in the corneocytes of stratum cornea resulting in an increased mobility of molecular components.1Holden, Brien Anthony. “Composition for Prevention and Treatment of Contact Lens Papillary Conjunctivitis and Allergic Eye Disease.” U.S. Patent Application No. 14/858,787.

Polyvinyl Alcohol as a synthetic resin with hydrophilic properties, it increases the persistence of tear film and therefore lubricates and soothes dry/irritated eyes.2Krishna, Narendra, and Frank Brow. “Polyvinyl Alcohol as an Ophthalmic Vehicle*: Effect on regeneration of corneal epithelium.” American journal of ophthalmology 57.1 (1964): 99-106.

INDICATIONS

It is used to improve the condition resulting from desiccation of cornea or tunica conjunctiva with insufficient production of tears 3Christie, Caroline. “Updated dry eye guide 2018.” Optician 2018.8 (2018): 178548-1., no matter whether this deficiency is cased by local defects in the eye or as a result of overall diseases; it is also used in connection with the tunica conjunctiva bag resulting from the failure to close eye-lids. – In addition to this, this drug is also used to moisten the eye in connection with the use of hard contact lenses. It is usually necessary to use the artificial tears for life. The medicament is for children and adults; However children suffer from tear production failure only quite exceptionally. Usually one drop is applied six times a day to the tunica conjunctiva bag.4Tost, Frank, et al. “Effect of different artificial tears against desiccation in cultured human epithelial cells.” Medical science monitor: international medical journal of experimental and clinical research 18.5 (2012): BR188.

DOSAGE AND ADMINISTRATION

Adults and children are fed six times a day 1 drop into the conjunctival sac. Do not consult with a doctor for up to 5 days.

ADVERSE EFFECTS

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Reporting of suspected adverse reactions:

The PPB Department of Pharmacovigilance was set up with a vision to develop, implement and continuously upgrade an appropriate system for detecting, reporting, and monitoring adverse drug reactions (ADRs) and other relevant problems with medicines in Kenya. The department strives to ensure the safety and efficacy of pharmaceutical products in Kenya.
Reporting suspected adverse reactions after authorization of the medicinal product are important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals/ Patients are encouraged to report any suspected adverse reactions via Pharmacovigilance Yellow Form, pv@pharmacyboardkenya.org or clicking below button:

Clinical | Pharmacokinetic data


Pregnancy Category:
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Protein Binding:
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Legal Status | Dosage forms & Strengths


Prescription Category:

Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:

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Drug Indentifiers:

Dexpanthenol

CAS Number
3D model (JSmol)
3DMet
Beilstein Reference
1724945, 1724947 R
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard100.036.839
EC Number
  • 240-540-6
KEGG
MeSHdexpanthenol
PubChem CID
RTECS number
  • ES4316500
UNII
CompTox Dashboard (EPA)


Drug Images

References/ Citation:

  1. Christie, Caroline. “Updated dry eye guide 2018.” Optician 2018.8 (2018): 178548-1.
  2. Tost, Frank, et al. “Effect of different artificial tears against desiccation in cultured human epithelial cells.” Medical science monitor: international medical journal of experimental and clinical research 18.5 (2012): BR188.
  3. Krishna, Narendra, and Frank Brow. “Polyvinyl Alcohol as an Ophthalmic Vehicle*: Effect on regeneration of corneal epithelium.” American journal of ophthalmology 57.1 (1964): 99-106.



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