Brands of Dexpanthenol Cream in Kenya
Bepanthen® Ointment , Bayer Consumer Care AG
Dexipan® Cream, Julphar pharmaceutical industries
MODE OF ACTION
Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium.
Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties
INDICATIONS
Coenzyme A (metabolite of Dexpanthenol) is important for deep penetrating moisturizer; stimulates epithelization; has wound healing effect; has an anti-inflammatory effect.
Only the D-Panthenol is the provitamin of D-Pantothenic acid (vitamin B5), not the L-Panthenol.
A cream / ointment with Dexpanthenol regularly applied to the skin improves the moisture content of dry skin significantly.
Accelerates the healing of superficial wounds by approximately 30%.
An ointment/cream with Dexpanthenol prevents erythema due to UV light.
Dexpanthenol also protects the lips against solar herpes, Sun burns, mild burns, skin irritations, dry or cracked skin, cosmetic or shaving rashes, post chemical peeling treatment, post laser resurfacing treatment ( 11th -15th day).
Dexpanthenol is effective for preventing / treating nappy dermatitis in infants.
DOSAGE AND ADMINISTRATION
Use Dexpanthenol cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Dexpanthenol cream is for external use only.
Apply Dexpanthenol cream directly to the affected areas once or twice daily, or as directed by your health care provider.
Wash and completely dry the affected area. Gently rub the medicine in until it is evenly distributed.
Wash your hands immediately after using Dexpanthenol cream, unless your hands are part of the treated area.
If you miss a dose of Dexpanthenol cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
CONTRAINDICATIONS
There are no known contraindications to the use of Dexpanthenol
DRUG INTERACTIONS
Dexpanthenol has no listed severe interactions with other drugs.
ADVERSE EFFECTS
burning, stinging, redness, or irritation may occur
Unusual changes in the skin (e.g., turning white/soft/soggy from too much wetness), signs of skin infection.
Allergic reaction : rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Reporting of suspected adverse reactions:
The PPB Department of Pharmacovigilance was set up with a vision to develop, implement and continuously upgrade an appropriate system for detecting, reporting, and monitoring adverse drug reactions (ADRs) and other relevant problems with medicines in Kenya. The department strives to ensure the safety and efficacy of pharmaceutical products in Kenya.
Reporting suspected adverse reactions after authorization of the medicinal product are important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals/ Patients are encouraged to report any suspected adverse reactions via Pharmacovigilance Yellow Form, pv@pharmacyboardkenya.org or clicking below button:
Dexpanthenol Cream in Kenya
Dexpanthenol Cream in Kenya
Dexpanthenol Cream in Kenya
Dexpanthenol Cream in Kenya
Dexpanthenol Cream in Kenya
Dexpanthenol Cream in Kenya
Bepanthen Ointment in Kenya
Bepanthen Ointment in Kenya
Dexipan Cream in Kenya
Dexipan Cream in Kenya
Clinical | Pharmacokinetic data
Pregnancy Category: Not Available
Routes of Administration: Topical
Bioavailability: Not Available
Protein Binding: Plasma protein binding have not been reported.
Metabolosim: Dexpanthenol is readily converted to pantothenic acid which is widely distributed into body tissues, mainly as coenzyme A.
Onset of Action: Not Available
Elimination Half life: Half life have not been reported
Excretion: About 70% of an oral dose of pantothenic acid is excreted unchanged in urine and about 30% in feces.
Legal Status | Dosage forms & Strengths
Prescription Category:
Prescription only Medicine (POM) , â„ž-only
Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:
This drug is not a controlled substance under Narcotic Drugs and Psychotropic Substances (Control ) Act
Dosage Forms | Strengths:
Drug Indentifiers:
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Beilstein Reference | 1724945, 1724947 R |
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Drug Images
References/ Citation:
- PPB Drugs Retention Register
- Ebner, Fritz, et al. “Topical use of dexpanthenol in skin disorders.” American journal of clinical dermatology 3.6 (2002): 427-433.
- Romiti, Ricardo, and Ney Romiti. “Dexpanthenol cream significantly improves mucocutaneous side effects associated with isotretinoin therapy.” Pediatric dermatology 19.4 (2002): 368-371.
- Heise, R., et al. “Dexpanthenol modulates gene expression in skin wound healing in vivo.” Skin pharmacology and physiology 25.5 (2012): 241-248.