Clindamycin

Clindamycin Chemical Structure: Clindamycin in Kenya

MOA: Clindamycin inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of the ribosome. Clindamycin is bacteriostatic.

Drug Label Information | Brands:

Brands of Clindamycin in Kenya

Clindar-B®, Wallace Pharmaceuticals PVT Limited
Clindacin®, Flamingo Pharmaceuticals Ltd.
Dacillin® ,Life Sciences PVT. Ltd
Dalacin-C®, Pfizer

Clindamycin was first made in 1966 or 1967.It is on the Kenya Essential Medicines List , which lists the most effective ,cost effective and safe medicines needed in a health system in Kenya.

Indications

Clindamycin is indicated in the treatment of serious infections caused by susceptible strains of the designated organisms in the conditions listed below:

  • Lower respiratory tract infections including pneumonia, empyema, and lung abscess caused by anaerobes, Streptococcus pneumoniae, other streptococci (except E. faecalis), and Staphylococcus aureus.
  • Skin and skin structure infections caused by Streptococcus pyogenes, Staphylococcus aureus, and anaerobes.
  • Gynecological infections including endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal cuff infection caused by susceptible anaerobes.
  • Intra-abdominal infections including peritonitis and intra-abdominal abscess caused by susceptible anaerobic organisms.
  • Septicemia caused by Staphylococcus aureus, streptococci (except Enterococcus faecalis), and susceptible anaerobes.
  • Bone and joint infections including acute hematogenous osteomyelitis caused by Staphylococcus aureus and as adjunctive therapy in the surgical treatment of chronic bone and joint infections due to susceptible organisms
  • .

    Drug interactions

    • clindamycin decreases effects of BCG vaccine live by pharmacodynamic antagonism.
    • clindamycin decreases effects of typhoid vaccine live by pharmacodynamic antagonism
    • clindamycin increases effects of Neuromascular Junction Blockers by pharmacodynamic synergism.
    • nitazoxanide, clindamycin.
      Either increases levels of the other by Mechanism: plasma protein binding competition

    Adverse Drug Effects of Clindamycin

    • Abdominal pain
    • Agranulocytosis
    • Eosinophilia
    • Fungal overgrowth
    • Pseudomembranous colitis
    • Hypersensitivity
    • Rashes
    • Urticaria
    • Hypotension

    You can get Cindamycin at Registered chemist near you