The bacterial activity of Ciprofloxacin results from interference with the enzyme DNA Gyrase which is needed for the synthesis of bacterial DNA
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When Ciprofloxacin is used topically , the systemic absorption of the antibiotic is minimal.In addition animal studies have shown no systemic toxicity in young animals using topical ciprofloxacin
Ciprofloxacin opthalmic is indicated for the treatment of infections caused by the susceptible strains of micro organisms the conditions listed below
Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae,Haemophillis influenzae.
For acute bacterial conjuctivitis,Ciprofloxacin is an excellent first line choice because it provides coverage of all the organisms that are most likely to cause ocular infection ,such as Staphylococcus ,Streptococcus , and Haemophilis influenzae
A number of studies have indicated that isolates from cases of bacterial conjuctivitis show the least resistance to Ciprofloxacin compared to many of the antibiotics that have traditionally been used.
Pseudomonas aeruginosa,Serratia marcescenes,Staphylococcus aureus, Staphylococcus epidermis,Streptococcus pneumoniae,Streptococcus (viridans Group)
Otitis externa, acute otitis media, chronic supperative otitis media and prophylaxis during otic surgeries such as mastoid surgery
Hypersensitivity to ciprofloxacin or any other component of the medication or hypersensitivity to other quinolones is a contraindication
Local burning or discomfort may be experienced .In corneal ulcers frequent use may reveal with precipitation .Remote cases of lid edema ,tearing ,photophobia ,corneal infiltrates ,nausea and decreased vision have been reported
Prolonged use may result in overgrowth of nonsuceptible organisms, including fungi