Chlorpromazine

Drug Label Information | Brands:

Brands of Chlorpromazine in Kenya

Chlorpromazine ,Biodeal Laboratories Ltd
Chlorpromed® ,Medisel Kenya Ltd
Medizine®, Medisel Kenya Ltd
Chlorpromazine , Laborate Pharmaceuticals India Limited
Chlorpromazine, Laboratory & Allied Ltd
Chlorpromazine, Nestor Pharmaceuticals Limited
Chlorpromazine, Cosmos Limited
Chlorpromazine, Elys Chemical Industries Ltd
Chlorpromazine, Vital Healthcare Ltd

PROPERTIES AND ACTION:

Chlorpromazine preparations contain Chlorpromazine hydrochloride a phenothiazine neuroleptic with a wide range of activity ranging from depressant actions on the central nervous system, alpha-adrenergic blocking and weaker antimuscarinic activities. It is a dopamine inhibitor and stimulates the release of prolactin. Other properties of Chlorpromazine hydrochloride include sedation, anti-emetic, serotonin blocking, weak anti-histamine, slight ganglion blocking, poikilothermy, relaxation of skeletal muscle and local anaesthetic effects.

INDICATIONS:

Chlorpromazine as a tranquillizer is used in the management of psychotic conditions e.g. schizophrenia and anxiety. As an antiemetic, it is used to control nausea and vomiting of a variety of diseases and also those caused by various drugs plus post-operative nausea and vomiting.

As an adjunct in the treatment of tetanus and cholera wherein the latter Chlorpromazine reduces the frequency and duration of diarrhoea, frequency of vomiting and the mean requirement for intravenous fluids. Chlorpromazine hydrochloride will be effective in the alleviation of intractable hiccups and treatment of hypertensive emergencies.

DOSAGE AND ADMINISTRATION:

Chlorpromazine tablets are administered by the oral route.

Dose:

Adults: Chlorpromazine tablets are administered at a close of 25 to 50 mg of the Chlorpromazine hydrochloride three times daily and increasing as necessary. Daily doses of 75mg may be given as a single dose at night although psychotic patients may require up to 1g or more. Lower doses of 10 to 25mg maybe sometimes required every 4-6 hours for the control of nausea and vomiting.

Children: 0.5mg per kg body weight every 4-6 hours by mouth for psychiatric conditions and children aged over 5 years is usually one-third to one-half the adult dose. Daily doses should not normally exceed 40mg for children aged 1 to 5 years or 75mg for children over 5 years of age.

PRECAUTIONS, WARNINGS AND SIDF-EFFECTS:

1. The patient should be advised to avoid alcohol and not drive a vehicle or operate machinery during the first few days of the treatment.

2. Avoid using concurrently, desferrioxamine, piperazine,
tricyclic antidepressants and anti parkinsonism agents.

3. Adverse effects include antimuscarinic effects e.g. hypotension, extrapyramidal disorders, disturbance of endocrine and sexual functions. Skin reactions including photosensitivity may occur and some extent of sedation at the beginning of treatment.

LEGAL CATEGORY: Prescription Only Medicine (POM).

THERAPEUTIC CATEGORY: ATC: N04A and N043 (Neuroleptic tranquillizer).