Chloramphenicol is a broad spectrum antibiotic with bacteriostatic activity and is effective against a wide range of gram-negative and gram-positive organisms including Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus, Streptococcus viridans, Moraxella species and Enterobacteriaceae, the main pathogens responsible for acute bacterial conjunctivitis. Chloramphenicol exerts its antibacterial effect by reversibly binding to bacterial ribosomes thereby inhibiting bacterial protein synthesis.
Drug Label Information | Brands:
Nicol®, West Coast
Chloramphenicol is a broad spectrum antibiotic indicated in both adults and children for the treatment of bacterial conjunctivitis caused by chloramphenicol susceptible organisms including : Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Streptococcus haemolyticus, Morax-axenfeld, Klebsiella/Enterobacter species and others.
• Hypersensitivity to the active substance , chloramphenicol or to any of the excipients
• Myelosuppression during previous exposure to chloramphenicol.
• Known personal or family history of blood dyscrasias including aplastic anaemia.
Chloramphenicol is absorbed systemically from the eye and toxicity has been reported following chronic exposure.
Bone marrow hypoplasia, including aplastic anaemia and death, has been reported following topical use of chloramphenicol. Whilst the hazard is a rare one, it should be borne in mind when assessing the benefits expected from the use of the compound.
Where chloramphenicol eye drops are used on a long-term or intermittent basis, it may be advisable to perform a routine blood profile before therapy and at appropriate intervals thereafter to detect any haemopoietic abnormalities.
Do not use for more than 5 days without consulting a doctor.