MOA: cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis
Drug Label Information | Brands:
Brands of Cefadroxil registered in Kenya
Actidrox®, Krishna Chemists Ltd
Adora®,Incepta Pharmaceuticals Limited
Biodroxil®, Sandoz GmbH Kundl
Bidcef®, Plethico
C-Drox®, Centurion Remedies Pvt. Ltd
Curisafe®, Pharco
Cedril®, Stallion
Cefamed®, Cipla
Cefdure®, Biodeal
Cefradox®, Aegis
Cesadroxyl®, Dabur
Cexil®, Leben
Drox®, Aurobindo
Duracef®, Bristol-Myers Squibb
Duraxyl®, Lab & Allied
Dawadroxyl®, Dawa Limited
Emdrox®, Medopharm
Flamicef®, Flamingo
Ibidroxil®, GSK
Mydrox®, National Pharmacy Limited
Ococef DT®, Ochoa
Ococef®, Ochoa
Odoxil®, Lupin
Rivadroxil®, Riva
Vedrox®, Indoco
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cephalexin
Indications:
Susceptible urinary tract, skin and skin structure infections, pharyngitis/tonsillitis, impetigo.
Drug interactions
The risk or severity of bleeding can be increased when Cefadroxil is combined with wafarin
Cefadroxil may decrease the excretion rate of Abacavir which could result in a higher serum level.
The therapeutic efficacy of Abciximab can be decreased when used in combination with Cefadroxil.
Cefadroxil may decrease the excretion rate of Acarbose which could result in a higher serum level.
Contraindications
Adults
Urinary Tract Infections: For uncomplicated lower urinary tract infections (i.e., cystitis) the usual dosage is 1 or 2 g per day in a single (q.d.) or divided doses (b.i.d.).
For all other urinary tract infections the usual dosage is 2 g per day in divided doses (b.i.d.).
Skin and Skin Structure Infections: For skin and skin structure infections the usual dosage is 1 g per day in single (q.d.) or divided doses (b.i.d.).
Pharyngitis and Tonsillitis: Treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis—1 g per day in single (q.d.) or divided doses (b.i.d.) for 10 days.
Children
For urinary tract infections, the recommended daily dosage for children is 30 mg/kg/day in divided doses every 12 hours. For pharyngitis, tonsillitis, and impetigo, the recommended daily dosage for children is 30 mg/kg/day in a single dose or in equally divided doses every 12 hours. For other skin and skin structure infections, the recommended daily dosage is 30 mg/kg/day in equally divided doses every 12 hours. In the treatment of beta-hemolytic streptococcal infections, a therapeutic dosage of cefadroxil should be administered for at least 10 days.
Precautions:
Side Effects:
- nausea, vomiting, stomach pain, mild diarrhea;
- stiff or tight muscles;
- joint pain;
- feeling restless or hyperactive;
- unusual or unpleasant taste in your mouth;
- mild itching or skin rash;
- vaginal itching or discharge.
Adverse Drug Reactions:
GI upset, anaphylaxis, rash; blood dyscrasias (rare).
Clinical Data / External Links / Attributes
| Strength | 125mg/5ml , 250mg/5ml suspension , 500mg |
| Formulation | capsules, suspension |
| Drug Category | Prescription Only Medicine |
| IUPAC name: | (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Chemical Formula: | C16H17N3O5S |
| PubChem : | 47964 |
| Wikipedia: | https://en.wikipedia.org/wiki/Cefadroxil |
| DrugBank | https://www.drugbank.ca/drugs/DB01140 |
| ChemSpider | http://www.chemspider.com/Chemical-Structure.43630.html |
| References: | References |
| 1. | Kenyapharmtech Druglist, drug monographs are based on drug manufacturers labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. |
| 2 | PPB retained Products List |
| 3 | http://www.toku-e.com/Assets/MIC/Cefadroxil.pdf |
| 4 | Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 493. ISBN 9783527607495. |
