Cefadroxil

MOA: cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis


Brands of Cefadroxil registered in Kenya
Actidrox®, Krishna Chemists Ltd
Adora®,Incepta Pharmaceuticals Limited
Biodroxil®, Sandoz GmbH Kundl
Bidcef®, Plethico
C-Drox®, Centurion Remedies Pvt. Ltd
Curisafe®, Pharco
Cedril®, Stallion
Cefamed®, Cipla
Cefdure®, Biodeal
Cefradox®, Aegis
Cesadroxyl®, Dabur
Cexil®, Leben
Drox®, Aurobindo
Duracef®, Bristol-Myers Squibb
Duraxyl®, Lab & Allied
Dawadroxyl®, Dawa Limited
Emdrox®, Medopharm
Flamicef®, Flamingo
Ibidroxil®, GSK
Mydrox®, National Pharmacy Limited
Ococef DT®, Ochoa
Ococef®, Ochoa
Odoxil®, Lupin
Rivadroxil®, Riva
Vedrox®, Indoco
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cephalexin
Indications:
Susceptible urinary tract, skin and skin structure infections, pharyngitis/tonsillitis, impetigo.
Drug interactions
The risk or severity of bleeding can be increased when Cefadroxil is combined with wafarin
Cefadroxil may decrease the excretion rate of Abacavir which could result in a higher serum level.
The therapeutic efficacy of Abciximab can be decreased when used in combination with Cefadroxil.
Cefadroxil may decrease the excretion rate of Acarbose which could result in a higher serum level.
Contraindications
Adults
Urinary Tract Infections: For uncomplicated lower urinary tract infections (i.e., cystitis) the usual dosage is 1 or 2 g per day in a single (q.d.) or divided doses (b.i.d.).
For all other urinary tract infections the usual dosage is 2 g per day in divided doses (b.i.d.).
Skin and Skin Structure Infections: For skin and skin structure infections the usual dosage is 1 g per day in single (q.d.) or divided doses (b.i.d.).
Pharyngitis and Tonsillitis: Treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis—1 g per day in single (q.d.) or divided doses (b.i.d.) for 10 days.
Children
For urinary tract infections, the recommended daily dosage for children is 30 mg/kg/day in divided doses every 12 hours. For pharyngitis, tonsillitis, and impetigo, the recommended daily dosage for children is 30 mg/kg/day in a single dose or in equally divided doses every 12 hours. For other skin and skin structure infections, the recommended daily dosage is 30 mg/kg/day in equally divided doses every 12 hours. In the treatment of beta-hemolytic streptococcal infections, a therapeutic dosage of cefadroxil should be administered for at least 10 days.
Precautions:
Side Effects:

  • nausea, vomiting, stomach pain, mild diarrhea;
  • stiff or tight muscles;
  • joint pain;
  • feeling restless or hyperactive;
  • unusual or unpleasant taste in your mouth;
  • mild itching or skin rash;
  • vaginal itching or discharge.

Adverse Drug Reactions:
GI upset, anaphylaxis, rash; blood dyscrasias (rare).

Clinical | Pharmacokinetic data


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Protein Binding:
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Legal Status | Dosage forms & Strengths


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References/ Citation:

Cefadroxil