Amoxicillin

Brands Of Amoxicillin in Kenya

Alimox®, Sphinx

Amolin®, Shelys

Amosun®, Zhuhai

Amoxapen®, Remedica

Amoxicap®,Namm Pharmaceuticals Co. Ltd

Amoxicillin, NVS Kenya Ltd

Amoxicillin ,Medico Remedies Pvt Ltd

Amoxicillin,Unisel

Amoxi-Denk®, Denk Pharma GmbH & Co. KG

Amoxigen, Shanghai Agen International Trade Co.ltd

Amoxil®, GSK

Amoximark®, Marksans

Amoximed , Medisel Kenya Ltd

Amyn®, Kopran Limited

Brumox® ,Brawn Laboratories Ltd.

Camox®, Cosmos Ltd

Caremox, Careplus ltd

Conamox ,Ratnamani Healthcare Private Limited

Elymox®, Elys Chemical Industries Ltd.

Gestamox®, Dinlas Pharma EPZ Limited

Imox®, IPCA

Kemoxyl®, Lab & Allied Ltd.

Labmox®,Laborate Pharmaceuticals India Limited

LC Mox, Reyoung Pharmaceuticals Co. Ltd

Medomox®, Medox Pharmaceuticals Ltd

Miloxy, Milan Laboratories (India) Pvt. Limited

Moxacil®, Dawa Limited

Moxacil Forte PFS ,Square Pharmaceuticals Ltd.

Moxilact , Crown Healthcare

Moxileb , Leben Laboratories PVT Ltd

Moximed®, Medivet Products Ltd

Moxper , Indchemie Health Specialities Pvt. Ltd.

MyDawa Amoxicillin , MyDawa Trading Ltd

Neomox®, Neopharma L.L.C.

Nesmox®,Nestor Pharmaceuticals Limited

Omacillin , National Pharmaceutical Industries Co. (SAOG)

Penamox®, GSK

Promox®,Medreich

Septimox,National Pharmacy Ltd

Spamox®, Kentons Limited

Tunamox 250 DT,Radiance Pharmaceuticals Ltd

Tycil Drops®, Beximco

Unixil®, Regal Pharmaceuticals Limited

Winpen®, Cadila pharm

Z mox®, Aurobindo

Zeemox®, Zest Pharma

Zenoxyl®, Zenufa Laboratories


Amoxicillin in Kenya : Cost , Prices,Brands,Chemical Structure
Amoxicillin Chemical Structure

MODE OF ACTION

Amoxicillin is a semisynthetic penicillin (beta-lactam antibiotic) that inhibits one or more enzymes (often referred to as penicillin-binding proteins, PBPs) in the biosynthetic pathway of bacterial peptidoglycan, which is an integral structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to weakening of the cell wall, which is usually followed by cell lysis and death.

Amoxicillin is susceptible to degradation by beta-lactamases produced by resistant bacteria and therefore the spectrum of activity of amoxicillin alone does not include organisms which produce these enzymes.

INDICATIONS

Amoxicillin is indicated for the treatment of the following infections in adults and children .

  • Acute bacterial sinusitis
  • Acute otitis media
  • Acute streptococcal tonsillitis and pharyngitis
  • Acute exacerbations of chronic bronchitis
  • Community acquired pneumonia
  • Acute cystitis
  • Asymptomatic bacteriuria in pregnancy
  • Acute pyelonephritis
  • Typhoid and paratyphoid fever
  • Dental abscess with spreading cellulitis
  • Prosthetic joint infections
  • Helicobacter pylori eradication
  • Lyme disease
  • Amoxicillin is also indicated for the prophylaxis of endocarditis.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.

DOSAGE AND ADMINISTRATION

Adults and children ≥40 kg

Indication*Dose*
Acute bacterial sinusitis250 mg to 500 mg every 8 hours or 750 mg to 1 g every 12 hours
Asymptomatic bacteriuria in pregnancy
Acute pyelonephritisFor severe infections 750 mg to 1 g every 8 hours

 

Acute cystitis may be treated with 3 g twice daily for one day

Dental abscess with spreading cellulitis
Acute cystitis
Acute otitis media500 mg every 8 hours, 750 mg to 1 g every 12 hours

 

For severe infections 750 mg to 1 g every 8 hours for 10 days

Acute streptococcal tonsillitis and pharyngitis
Acute exacerbations of chronic bronchitis
Community acquired pneumonia500 mg to 1 g every 8 hours
Typhoid and paratyphoid fever500 mg to 2 g every 8 hours
Prosthetic joint infections500 mg to 1 g every 8 hours
Prophylaxis of endocarditis2 g orally, single dose 30 to 60 minutes before procedure
Helicobacter pylori eradication

750 mg to 1 g twice daily in combination with a proton pump inhibitor (e.g. omeprazole, lansoprazole) and another antibiotic (e.g. clarithromycin, metronidazole) for 7 days

Lyme disease

Early stage: 500 mg to 1 g every 8 hours up to a maximum of 4 g/day in divided doses for 14 days (10 to 21 days)

Late stage (systemic involvement): 500 mg to 2 g every 8 hours up to a maximum of 6 g/day in divided doses for 10 to 30 days

*Consideration should be given to the official treatment guidelines for each indication

Children <40 kg

Children may be treated with Amoxicillin capsules capsules, dispersible tablets suspensions or sachets. Amoxicillin capsules Paediatric Suspension is recommended for children under six months of age.

Children weighing 40 kg or more should be prescribed the adult dosage. Recommended doses:

Indication+Dose+
Acute bacterial sinusitis20 to 90 mg/kg/day in divided doses*
Acute otitis media
Community acquired pneumonia
Acute cystitis
Acute pyelonephritis
Dental abscess with spreading cellulitis
Acute streptococcal tonsillitis and pharyngitis40 to 90 mg/kg/day in divided doses*
Typhoid and paratyphoid fever100 mg/kg/day in three divided doses
Prophylaxis of endocarditis50 mg/kg orally, single dose 30 to 60 minutes before procedure
Lyme diseaseEarly stage: 25 to 50 mg/kg/day in three divided doses for 10 to 21 days

Late stage (systemic involvement): 100 mg/kg/day in three divided doses for 10 to 30 days

+ Consideration should be given to the official treatment guidelines for each indication.

 

*Twice daily dosing regimens should only be considered when the dose is in the upper range.

Elderly

No dose adjustment is considered necessary.

CONTRAINDICATIONS

A history of allergic reaction to any of the penicillins is a contraindication.

DRUG INTERACTIONS:

Probenecid

Concomitant use of probenecid is not recommended. Probenecid decreases the renal tubular secretion of amoxicillin. Concomitant use of probenecid may result in increased and prolonged blood levels of amoxicillin.

Allopurinol

Concurrent administration of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions.

Tetracyclines

Tetracyclines and other bacteriostatic drugs may interfere with the bactericidal effects of amoxicillin.

Oral anticoagulants

Oral anticoagulants and penicillin antibiotics have been widely used in practice without reports of interaction. However, in the literature there are cases of increased international normalised ratio in patients maintained on acenocoumarol or warfarin and prescribed a course of amoxicillin. If co-administration is necessary, the prothrombin time or international normalised ratio should be carefully monitored with the addition or withdrawal of amoxicillin. Moreover, adjustments in the dose of oral anticoagulants may be necessary.

Methotrexate

Penicillins may reduce the excretion of methotrexate causing a potential increase in toxicity.

ADVERSE REACTIONS

Gastrointestinal: Nausea, vomiting, diarrhea, and hemorrhagic / pseudomembranous colitis.
Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment.

Hypersensitivity Reactions: Serum sickness–like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis and urticaria have been reported.

Liver: A moderate rise in AST (SGOT) and/or ALT (SGPT) has been noted, but the significance of this finding is unknown. Hepatic dysfunction including cholestatic jaundice, hepatic cholestasis and acute cytolytic hepatitis have been reported.

Renal: Crystalluria has also been reported

Hemic and Lymphatic Systems: Anemia, including hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena.

Central Nervous System: Reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, and/or dizziness have been reported rarely.

Miscellaneous: Tooth discoloration (brown, yellow, or gray staining) has been rarely reported. Most reports occurred in pediatric patients. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases.

Reporting a Suspected Drug Reaction:

The PPB Department of Pharmacovigilance was set up with a vision to develop, implement and continuously upgrade an appropriate system for detecting, reporting and monitoring adverse drug reactions (ADRs) and other relevant problems with medicines in Kenya. The department strives to ensure the safety and efficacy of pharmaceutical products in Kenya.
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals/ Patients  are encouraged  to report any suspected adverse reactions via Pharmacovigilance Forms , pv@pharmacyboardkenya.org or clicking below button:


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Clinical | Pharmacokinetic data


Pregnancy Category: A
Routes of Administration: By mouth, intravenous
Bioavailability: 95% by mouth
Protein Binding: Amoxicillin is 17% protein bound in serum
Metabolosim: less than 30% biotransformed in liver
Onset of Action: Not Available
Elimination Half life: 61.3 minutes
Excretion: Kidneys

Legal Status | Dosage forms & Strengths


Prescription Category:
Prescription only Medicine (POM) , ℞-only
Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:
This drug is not a controlled substance under Narcotic Drugs and Psychotropic Substances (Control ) Act
Dosage Forms | Strengths:
Tablets | Injectable | Capsules

Drug Indentifiers:

CAS Number
PubChem
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard


Drug Images

References/ Citation:




What was the patient being treated for
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