Aceclofenac / Thiocolchicoside

Aceclofenac / Thiocolchicoside Combination in Kenya

Acepar Plus, Dawa limited

Aflodor, Inventia Healthcare Pvt. Ltd.

Bakwel-A, Pulse Pharmaceuticals Private Limited


Thiocolchicoside Chemical Structure: Thiocolchicoside in Kenya
Thiocolchicoside Chemical Structure
Aceclofenac in Kenya
Aceclofenac Chemical Structure

MODE OF ACTION

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.
Aceclofenac potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever.

Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent.

INDICATIONS

Thiocolchicoside /Aceclofenac  is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

Muscles stiffness in spinal

Muscles stiffness in muscle diseases

Muscles stiffness in the joint diseases

Lumbago

Muscles stiffness in nerve diseases

Pain caused by Nonarticular rheumatism

Rheumatoid arthritis

Osteoarthritis

Ankylosing spondylitis

Periarthritis of scapulohumerous

Ischiadynia

DOSAGE AND ADMINISTRATION

CONTRAINDICATIONS

Aceclofenac

Hypersensitivity to Aceclofenac or to any of the excipients.

Active, or history of recurrent peptic ulcer/haemorrhage (two or more distinct episodes of proven ulceration or bleeding).

NSAIDS are contraindicated in patients who have previously shown hypersensitivity reactions (eg. Asthma, rhinitis, angioedema or urticaria) in response to ibuprofen, aspirin, or other non-steroidal anti-inflammatory drugs.

Hepatic failure and renal failure.

Patients with established congestive heart failure (NYHA II-IV), ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.

History of gastrointestinal bleeding or perforation, related to previous NSAIDS therapy.

Active bleedings or bleeding disorders.

Aceclofenac should not be prescribed during pregnancy, especially during the last trimester of pregnancy, unless there are compelling reasons for doing so. The lowest effective dosage should be used .

Thiocolchicoside

Thiocolchicoside must not be used

– in patients hypersensitive to the active substance or to any of the excipients

– during the entire pregnancy period

– during lactation

– in women of childbearing potential not using contraception

ADVERSE EFFECTS

The following is a list of possible side-effects that may occur from all constituting ingredients of This combination. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
Abdominal pain
Rash
Drowsiness
Gas
Allergen
Allergy
Sleepiness weakness
Headache
Diarrhoea
Allergic
Urge to vomit
Brief loss of consciousness
Symptoms due to exposure to sunlight
Dyspepsia
Nausea
Urticaria
Enuresis
Dizziness
Thiocolchicoside/Aceclofenac may also cause side-effects not listed here.

Clinical | Pharmacokinetic data


Pregnancy Category: C
Routes of Administration: Oral
Bioavailability:
Protein Binding:
Metabolosim:
Onset of Action:
Elimination Half life:
Excretion: Not Available

Legal Status | Dosage forms & Strengths


Prescription Category:
Prescription only Medicine (POM) , ℞-only
Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:
This drug is not a controlled substance under Narcotic Drugs and Psychotropic Substances (Control ) Act
Dosage Forms | Strengths:
Tablets

Drug Indentifiers:

Thiocolchicoside

CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard

Aceclofenac:

CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard


Drug Images

References/ Citation:

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