Aceclofenac / Thiocolchicoside Combination in Kenya
Acepar Plus, Dawa limited
Aflodor, Inventia Healthcare Pvt. Ltd.
Bakwel-A, Pulse Pharmaceuticals Private Limited
MODE OF ACTION
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.
Aceclofenac potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever.
Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent.
Thiocolchicoside /Aceclofenac is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
Muscles stiffness in spinal
Muscles stiffness in muscle diseases
Muscles stiffness in the joint diseases
Muscles stiffness in nerve diseases
Pain caused by Nonarticular rheumatism
Periarthritis of scapulohumerous
DOSAGE AND ADMINISTRATION
Hypersensitivity to Aceclofenac or to any of the excipients.
Active, or history of recurrent peptic ulcer/haemorrhage (two or more distinct episodes of proven ulceration or bleeding).
NSAIDS are contraindicated in patients who have previously shown hypersensitivity reactions (eg. Asthma, rhinitis, angioedema or urticaria) in response to ibuprofen, aspirin, or other non-steroidal anti-inflammatory drugs.
Hepatic failure and renal failure.
Patients with established congestive heart failure (NYHA II-IV), ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.
History of gastrointestinal bleeding or perforation, related to previous NSAIDS therapy.
Active bleedings or bleeding disorders.
Aceclofenac should not be prescribed during pregnancy, especially during the last trimester of pregnancy, unless there are compelling reasons for doing so. The lowest effective dosage should be used .
Thiocolchicoside must not be used
– in patients hypersensitive to the active substance or to any of the excipients
– during the entire pregnancy period
– during lactation
– in women of childbearing potential not using contraception
The following is a list of possible side-effects that may occur from all constituting ingredients of This combination. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
Urge to vomit
Brief loss of consciousness
Symptoms due to exposure to sunlight
Thiocolchicoside/Aceclofenac may also cause side-effects not listed here.
Clinical | Pharmacokinetic data
Pregnancy Category: C
Routes of Administration: Oral
Onset of Action:
Elimination Half life:
Excretion: Not Available
Legal Status | Dosage forms & Strengths
Prescription only Medicine (POM) , ℞-only
Narcotic Drugs and Psychotropic Substances (Control ) Act Schedule:
This drug is not a controlled substance under Narcotic Drugs and Psychotropic Substances (Control ) Act
Dosage Forms | Strengths:
|CompTox Dashboard (EPA)|
|CompTox Dashboard (EPA)|