3rd Generation Cephalosporins

Third-generation agents include cefoperazone, cefotaxime, ceftazidime,ceftizoxime, ceftriaxone, cefixime, cefpodoxime proxetil, cefdinir, cefditoren pivoxil, ceftibuten, and moxalactam.

Compared with second generation cephalosporins ,these agents have expanded gram-negative spectrum and some are able to cross the blood-brain barrier.They are active against Citrobacter, S.marcescens ,Providencia (resistance has been noted)

They are also active against β-lactamase producing strains of haemophilus and neisseria.

Below are some of Third Generation Cephalosporins available in Kenya :

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