Drug Class: Sulphonamides

Co-trimoxazole

Co-trimoxazole MODE OF ACTION Co-trimoxazole is generally bactericidal; it acts by sequential blockade of folic acid enzymes in the synthesis pathway. The sulfamethoxazole component inhibits formation of dihydrofolic acid from para-aminobenzoic (PABA), whereas trimethoprim inhibits dihydrofolate reductase. Brands of CO-trimoxazole in Kenya Alprim, Elys Bactrim, Roche Biotrim, Biodeal Ciplin, Cipla Cosatrim, Cosmos Cotreich, GSK Cotrimoxazole, …

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Sulphadiazine

Sulphadiazine Mode of Action: The systemic sulfonamides are bacteriostatic agents having a similar spectrum of activity. Sulfonamides competitively inhibit bacterial synthesis of folic acid (pteroylglutamic acid) from aminobenzoic acid. Resistant strains are capable of utilizing folic acid precursors or preformed folic acid. Brands of Sulfadiazine in Kenya NO BRANDS IS REGISTERED BY PPB CURRENTLY INDICATIONS …

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