Drug Class: Macrolides

Erythromycin

Mechanism of Action Erythromycin and other macrolide antibiotics inhibit protein synthesis by binding to the 23S rRNA molecule (in the 50S subunit) of the bacterial ribosome blocking the exit of the growing peptide chain of sensitive microorganism Mechanism of Resistance The major route of resistance is modification of the 23S rNA in the 50S ribosomal …

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Azithromycin

Mechanism of Action: Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis. Nucleic acid synthesis is not affected. Brands of Azithromycin in Kenya Agycin, Bliss GVS Pharma Ltd. ATM, Indoco Remedies Limited Azal, Medox Pharmaceuticals Ltd Azaltic , Nirpo Jmi Pharma Ltd Azar, Ochoa Azbact …

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Clarithromycin

MOA :Clarithromycin exerts its antibacterial action by binding to the 50S ribosomal subunit of susceptible bacteria resulting in inhibition of protein synthesis. Resistance The major routes of resistance are modification of the 23S rRNA in the 50S ribosomal subunit to insensitivity or drug efflux pumps. Beta-lactamase production should have no effect on clarithromycin activity. Most …

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Spectinomycin

Mechanism of Action : Inhibits protein synthesis in bacterial cell by binding reversibly to the P site on the 50S subunit of the bacterial ribosome. This action is considered to be bacteriostatic Brands Spectinomycin in Kenya: Gono®, Lab and Allied Togamycin®, Pfizer Togozed®, Zawadi Healthcare Ltd INDICATIONS: Gonorrhea caused by penicillin-resistant bacteria or in patients …

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Fidaxomicin

Fidaxomicin Mechanism of Action: Fidaxomicin is a fermentation product obtained from the Actinomycete Dactylosporangium aurantiacum. Fidaxomicin is bactericidal against C. difficile in vitro, inhibiting RNA synthesis by RNA polymerases, and demonstrates a post-antibiotic effect vs. C. difficile of 6-10 hrs. Brands of Fidaxomicin in Kenya NB: Fidaxomicin is not available in Kenya ,and its not …

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Azithromycin/ Fluconazole/ Secnidazole

Brands of Azithromycin / Fluconazole / Secnidazole in Kenya: BTC Kit®, Lincoln Pharmaceuticals Ltd Combisaf® , Shambhuprasad And Sons Dazel kit®, Ajanta Pharma Limited G-CURE®, Fredun Pharmaceutical Ltd Gynagone Kit®, Laboratory & Allied Gynokit®, Plethico Gyncure Kit®, PSM Pharmaceuticals Ltd Her Kit®, Zawadi Healthcare Ltd UTI®, United Pharma (K) Limited Vastkit® , Daima Dispensing Chemists …

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