Drug Class: Anti-Tuberculous Drugs

Streptomycin

Mechanism of Action: Streptomycin is a protein synthesis inhibitor. It binds to the small 16S rRNA of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit. Brands of Streptomycin In Kenya: Carestrep , Careplus Limited Strepto 1, Crown Healthcare Streptomycin, Dawa Streptomycin , Macleods Pharmaceuticals Limited INDICATIONS: …

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Cycloserine

Mode of Action Cycloserine works as an antibiotic by inhibiting cell-wall biosynthesis in bacteria. As a cyclic analogue of D-alanine, cycloserine acts against two crucial enzymes important in the cytosolic stages of peptidoglycan synthesis: alanine racemase (Alr) and D-alanine:D-alanine ligase (Ddl). Brands of Cycloserine in Kenya Coxerin, Macleods Pharmaceuticals Limited Cycloserine, Eli Lilly INDICATIONS: Cycloserine …

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Ethambutol

Mechanism of Action: The mechanism of action of ethambutol is not completely known. There is evidence that the drug exerts its bacteriostatic activity by virtue of inhibition of arabinosyl transferase, an enzyme that polymerizes arabinose into arabinan and then arabinogalactan, a mycobacterial cell wall constituent. Brands of Ethambutol in Kenya Etham-400,Cosmos Limited Combutol, Lupin Ethambutol …

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Rifampicin / Ethambutol / Pyrazinamide / Isoniazid

MODE OF ACTION: Rifampicin inhibits the DNA-dependent RNA polymerase of sensitive bacterial strains, but without affecting the host enzymatic systems. Isoniazid exerts a bactericidal effect mainly on rapidly growing populations of Mycobacterium tuberculosis. Its mechanism of action is probably based chiefly on inhibition of mycolic acid synthesis, mycolic acid being an important constituent of the …

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Rifampicin / Isoniazid

MODE OF ACTION Rifampicin inhibits the DNA-dependent RNA polymerase of sensitive bacterial strains, but without affecting the host enzymatic systems. Isoniazid exerts a bactericidal effect mainly on rapidly growing populations of Mycobacterium tuberculosis. Its mechanism of action is probably based chiefly on inhibition of mycolic acid synthesis, mycolic acid being an important constituent of the …

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Isoniazid

ISONIAZID MODE OF ACTION: Isoniazid inhibits the synthesis of mycolic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Brands of Isoniazid in Kenya Bitub®, Yuria Pharma Limited Isoniazid, Macleods Pharmaceuticals Limited Isoniazid, Cosmos Limited Isozide® , Nabiqasim Industries (Pvt). …

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Pyrazinamide

Mechanism of Action of Pyrazinamide: Pyrazinamide is a prodrug that stops the growth of M. tuberculosis. Pyrazinamide diffuses into the granuloma of M. tuberculosis, where the tuberculosis enzyme pyrazinamidase converts pyrazinamide to the active form pyrazinoic acid. Brands of Pyrazinamide in Kenya Macrozide® , Macleods Pharmaceuticals Limited PZA®, Cosmos Limited Pyrazina®, Lupin Pyrazinamide , Macleods …

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Rifabutin

MODE OF ACTION OF RIFABUTIN: Rifabutin acts via the inhibition of DNA-dependent RNA polymerase in gram-positive and some gram-negative bacteria, leading to a suppression of RNA synthesis and cell death. Brands of Rifabutin  in Kenya: Mycobutin®, Pfizer INDICATIONS: Rifabutin is indicated for: – the prophylaxis of M. avium intracellulare complex (MAC) infections in patients with …

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Rifampicin

Rifampicin Mode of Action: Rifampicin inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase. Crystal structure data and biochemical data suggest that rifampicin binds to the pocket of the RNA polymerase β subunit within the DNA/RNA channel, but away from the active site. Brands of Rifampicin Macox® , Macleods Pharmaceuticals Limited R-cin®, Lupin …

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