Drug Class: Aminoglycosides

Amikacin

MOA : Amikacin is a polycationic, semisynthetic, bactericidal aminoglycoside. Amikacin enters the bacterial cell by binding to negatively charged components of the bacterial cell wall disrupting the overall architecture of the cell wall. The primary mechanism of action is the disruption and inhibition of protein synthesis in the target bacteria by binding to the 30S …

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Streptomycin

Mechanism of Action: Streptomycin is a protein synthesis inhibitor. It binds to the small 16S rRNA of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit. Brands of Streptomycin In Kenya: Carestrep , Careplus Limited Strepto 1, Crown Healthcare Streptomycin, Dawa Streptomycin , Macleods Pharmaceuticals Limited INDICATIONS: …

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Gentamicin

MOA: Gentamicin, an aminoglycoside, binds to the prokaryotic ribosome, inhibiting protein synthesis in susceptible bacteria.  It is bactericidal in vitro against Gram-positive and Gram-negative bacteria. Brands of Gentamicin in Kenya Caregenta-80 , Careplus ltd Dawagenta, Dawa limited Genacyn, Square Pharmaceuticals Ltd. Gentagen, Shanghai Agen International Trade Co.ltd Gentamed , Medisel Kenya Limited Gentamycin, Fresenius Kabi …

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Kanamycin A

Mechanism of Action: Kanamycin works by interfering with protein synthesis. It binds to the 30S subunit of the bacterial ribosome. This results in incorrect alignment with the mRNA and eventually leads to a misread that causes the wrong amino acid to be placed into the peptide. Brands of Kanamycin in Kenya: Dawa-cin®, Dawa Kanamed , …

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Aminosidine (Paromomycin)

Paromomycin ( Aminosidine) Mechanism (Mode ) of Action Paromomycin is a protein synthesis inhibitor in nonresistant cells by binding to 16S ribosomal RNA. This broad-spectrum antibiotic soluble in water, is very similar in action to neomycin. Brands of Aminosidine (Paromomycin) in Kenya Considine®, Concepts Daboral®, Cosmos Limited Gabbrolal®, Pfizer Gaberol®, Oss-Chemie Minodine®, Dawa Limited Unibrol®, …

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