Drug Class: 2nd Generation Cephalosporins

Cefaclor

Mechanism of Action As with other cephalosporins, the bactericidal action of cefaclor results from inhibition of cell-wall synthesis. Mechanism of Resistance Resistance to cefaclor is primarily through hydrolysis of beta-lactamases, alteration of penicillin binding proteins (PBPs) and decreased permeability. Pseudomonas spp., Acinetobacter calcoaceticus and most strains of Enterococi (Enterococcus faecalis, group D streptococci), Enterobacter spp., …

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Cefprozil

Brand Names of Cefprozil in Kenya Aurozil®, Aurobindo Pharma Ltd Cefzil®, Bristol-Myers Squibb Zilab , Laboratory & Allied Ltd Mechanism of Action Second-generation cephalosporin that binds to one or more of the penicillin-binding proteins, which in turn inhibits cell wall synthesis and results in bactericidal activity. Has gram-positive activity that first-generation cephalosporins have and adds …

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